公开(公告)号：EP3280702A1

公开(公告)日：2018-02-14

申请号：EP16777191.4

申请日：2016-04-06

申请人： The Trustees of The University of Pennsylvania

发明人： RIDKY, Todd ,  NATALE, Chris ,  WINKLER, Jeffrey ,  COOKSON, Rosa Ellen

IPC分类号： C07D221/16 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P17/16 ,  A61P17/18

CPC分类号： C07D405/04 ,  A61K8/49 ,  A61P17/00 ,  A61P17/06 ,  A61P17/14 ,  A61P17/16 ,  A61P17/18 ,  A61Q17/04 ,  A61Q19/02 ,  C07D221/16 ,  C07D491/048

摘要： The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR).