公开(公告)号：EP3328500A1

公开(公告)日：2018-06-06

申请号：EP16831347.6

申请日：2016-07-28

申请人： The Trustees of the University of Pennsylvania

发明人： COTSARELIS, George ,  ZHENG, Ying ,  O'BRIEN, Joan ,  COLLINS, David W. ,  HSIEH, Jen-Chih

IPC分类号： A61Q7/00 ,  A61P17/00 ,  A61P17/14 ,  A61K38/57

CPC分类号： A61Q7/00 ,  A61K8/368 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/69 ,  A61K31/473 ,  A61K31/506 ,  A61K38/00 ,  A61K2800/92 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

摘要： DP-2 antagonists reversed PGD2-mediated human hair growth inhibition in a dose-dependent manner in vitro by reducing PGD2-triggered apoptosis and maintaining proliferation of keratinocytes. Hair follicles from approximately half of the alopecia patients exhibited little susceptibility to PGD2's effect in vitro. SNPs in the human DP-2 gene were identified that are associated with hair growth inhibition by PGD2. These findings underscore the role of DP-2 in regulating hair growth and indicate that DP-2 can be an effective approach in preventing and/or treating androgenetic alopecia in patients sensitive to PGD2. Furthermore, the SNPs identified here can be used to identify patients who will benefit from treatment.