专利检索 ap:("The Trustees of the University of Pennsylvania" OR "The Wistar Institute Of Anatomy AND Biology") AND inv:"WANG, Liang-Chuan" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR TARGETING STROMAL CELLS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：组合物和方法从基质瞄准癌症治疗

公开(公告)号：EP2904106A2

公开(公告)日：2015-08-12

申请号：EP13843099.6

申请日：2013-09-30

申请人： The Trustees of the University of Pennsylvania , The Wistar Institute Of Anatomy And Biology

发明人： JUNE, Carl, H. , PURE, Ellen , WANG, Liang-Chuan , ALBELDA, Steven , SCHOLLER, John

IPC分类号： C12P21/08 , C12P19/34 , A61K48/00

CPC分类号： C07K16/40 , A61K35/17 , A61K39/0011 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/622 , C07K2317/73 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/70 , C12N2710/10343

摘要： The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.