公开(公告)号：EP3218397A1

公开(公告)日：2017-09-20

申请号：EP15797815.6

申请日：2015-11-13

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Corti, Davide ,  The United States Government, as represented by The Secretary of The Army ,  Humabs Biomed S.A. ,  Institute for Research in Biomedicine

发明人： CORTI, Davide ,  LANZAVECCHIA, Antonio ,  TREFRY, John ,  SULLIVAN, Nancy ,  MULANGU, Sabue ,  GRAHAM, Barncy ,  MUYEMBE-TAMFUN, Jean-Jacques ,  LEDGERWOOD, Julie ,  STANLEY, Daphne

IPC分类号： C07K16/10

CPC分类号： C07K16/10 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N2333/08

摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

摘要翻译： 公开了特异性结合埃博拉病毒糖蛋白的中和抗体和抗原结合片段。 还提供了编码这些抗体的核酸，载体和宿主细胞。 公开了使用抗体和抗原结合片段检测埃博拉病毒的方法。 例如，抗体，抗原结合片段，核酸和载体可用于预防和/或治疗受试者中的埃博拉病毒感染。