公开(公告)号：EP3649133A1

公开(公告)日：2020-05-13

申请号：EP18745789.0

申请日：2018-07-05

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Fundació Institut Català d'Investigació Química ,  University of Delaware ,  University of Leeds ,  Universitat Rovira I Virgili

发明人： BEUTLER, John, A. ,  ECHAVARREN, Antonio ,  CHAIN, William ,  BEECH, David ,  WU, Zhenhua ,  SUPPO, Jean-Simon ,  BRAVO, Fernando ,  RUBAIY, Hussein

IPC分类号： C07D493/08 ,  A61K31/35 ,  A61P35/00

公开(公告)号：EP3283489B1

公开(公告)日：2019-08-21

申请号：EP16718144.5

申请日：2016-04-13

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  Fundació Institut Català d'investigació Quimica ,  Universitat Rovira I Virgili

发明人： BEUTLER, John A. ,  ECHAVARREN, Antonio M. ,  LOPEZ, Laura ,  BRAVO, Fernando ,  RIESGO, Lorena ,  RANSOM, Tanya Tannaquil

IPC分类号： C07D487/08 ,  C07D493/08 ,  C07D495/08 ,  A61K31/35 ,  A61P35/00

公开(公告)号：EP3283489A1

公开(公告)日：2018-02-21

申请号：EP16718144.5

申请日：2016-04-13

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  Fundació Institut Català d'investigació Quimica ,  Universitat Rovira I Virgili

发明人： BEUTLER, John A. ,  ECHAVARREN, Antonio M. ,  LOPEZ, Laura ,  BRAVO, Fernando ,  RIESGO, Lorena ,  RANSOM, Tanya Tannaquil

IPC分类号： C07D487/08 ,  C07D493/08 ,  C07D495/08 ,  A61K31/35 ,  A61P35/00

CPC分类号： C07D493/08 ,  A61P3/10 ,  A61P35/02 ,  C07D487/08 ,  C07D495/08

摘要： Disclosed is a compound of formula (I) in which R1-R5 and X1 are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer and a method of treating diabetes.