公开(公告)号：EP3154581B1

公开(公告)日：2019-02-20

申请号：EP15747597.1

申请日：2015-06-15

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Janssen Biotech, Inc.

发明人： CHILDS, Richard, W. ,  BERG, Maria ,  CALDERON, Luis, Espinoza ,  SASSER, Kate ,  ATTAR, Ricardo

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  A61P37/00

公开(公告)号：EP3154581A1

公开(公告)日：2017-04-19

申请号：EP15747597.1

申请日：2015-06-15

申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Janssen Biotech, Inc.

发明人： CHILDS, Richard, W. ,  BERG, Maria ,  CALDERON, Luis, Espinoza ,  SASSER, Kate ,  ATTAR, Ricardo

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2896 ,  A61K39/39558 ,  A61P35/02 ,  A61P37/00 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/73 ,  C07K2317/732 ,  A61K2300/00

摘要： Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 F(ab′)2 fragment and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 F(ab′)2 fragment and 2) an anti-CD38 antibody, in either order or simultaneously.

摘要翻译： 本文提供了通过使表达CD38的细胞与1）结合抗CD38F（ab'）2片段的NK细胞和2）抗CD38抗体以任何顺序接触来抑制表达CD38的细胞的生长或增殖的方法 或同时进行。 本文还提供了通过向受试者施用1）与抗CD38F（ab'）2片段结合的NK细胞和2）抗CD38抗体治疗或抑制受试者过度增殖性病症或自身免疫病症的方法， 以任何顺序或同时进行。