专利检索 ap:("The University Court of the University of Edinburgh") AND inv:"SIMMONDS, Peter" 第 1 页

1.

发明授权
ENHANCED EXPRESSION OF RNA VECTORS 有权

公开(公告)号：EP2978850B1

公开(公告)日：2019-04-17

申请号：EP14714776.3

申请日：2014-03-24

申请人： The University Court of the University of Edinburgh

发明人： SIMMONDS, Peter

IPC分类号： C12N15/86

2.

发明公开
ENHANCED EXPRESSION OF RNA VECTORS 审中-公开
标题翻译： VERSTÄRKTEEXPRESSION VON RNA-VEKTOREN

公开(公告)号：EP2978850A1

公开(公告)日：2016-02-03

申请号：EP14714776.3

申请日：2014-03-24

申请人： The University Court of the University of Edinburgh

发明人： SIMMONDS, Peter

IPC分类号： C12N15/86

CPC分类号： C12N15/86 , C12N2760/16143 , C12N2770/32043

摘要： The present invention relates to methods and compositions for enhancing expression from RNA expression vectors. The invention is based upon the observation that reducing the frequency of the dinucleotides CpG and UpA has a significant effect on expression from such vectors. Aspects of the invention include, amongst others, synthetic RNA vectors, virions, cells, methods of producing vaccines and methods of treatment or immunisation.

摘要翻译： 本发明涉及用于增强RNA表达载体表达的方法和组合物。本发明基于以下观察：降低二核苷酸CpG和UpA的频率对来自这些载体的表达具有显着影响。本发明的方面包括合成RNA载体，病毒粒子，细胞，生产疫苗的方法和治疗或免疫方法。