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1.发明授权PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT 有权用于癌症治疗的含有环状N-杂环碳烯配合物的药物组合物
公开(公告)号：EP2493896B1
公开(公告)日：2017-04-26
申请号：EP10825938.3
申请日：2010-10-27
发明人： CHE, Chiming , SUN, Waiyin, Raymond , CHOW, Lokfung , YAN, Jing
IPC分类号： C07F1/12 , C07F17/02 , C07F17/00 , C08F132/00 , C08F134/00 , A61K31/787 , A61K35/00 , A61P35/04 , A61P35/02
CPC分类号： C07F15/0086 , A61K31/555 , C07F1/00
摘要： The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase.
摘要翻译： 本公开涉及用于治疗癌症的药物组合物，其包含环金属化的N-杂环卡宾络合物。 环金属化的N-杂环卡宾络合物含有金（III）或铂（II）原子。 该药物组合物具有抗癌活性，如诱导细胞死亡，抑制细胞增殖，抑制拓扑异构酶和/或中毒拓扑异构酶。
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2.发明公开PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT 有权与ZYKLOMETALLIERTEN N-杂环卡宾用于癌症治疗的药物组合物
公开(公告)号：EP2493896A1
公开(公告)日：2012-09-05
申请号：EP10825938.3
申请日：2010-10-27
发明人： CHE, Chiming , SUN, Waiyin, Raymond , CHOW, Lokfung , YAN, Jing
IPC分类号： C07F1/12 , C07F17/02 , C07F17/00 , C08F132/00 , C08F134/00 , A61K31/787 , A61K35/00 , A61P35/04 , A61P35/02
CPC分类号： C07F15/0086 , A61K31/555 , C07F1/00
摘要： The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase.
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