公开(公告)号：EP3601301A1

公开(公告)日：2020-02-05

申请号：EP18715947.0

申请日：2018-03-29

申请人： The University of Liverpool ,  The Johns Hopkins University

发明人： RANNARD, Steven Paul ,  OWEN, Andrew ,  CURLEY, Paul ,  HOBSON, James ,  SICCARDI, Marco ,  FREEL MEYERS, Caren L. ,  AL-KHOUJA, Amer ,  MEYERS, David J. ,  FLEXNER, Charles Williams

IPC分类号： C07F9/6561 ,  A61K31/513 ,  A61K31/675 ,  C07D411/04 ,  A61P35/00 ,  A61P31/18 ,  A61K9/00 ,  A61K47/00 ,  A61K9/51

公开(公告)号：EP3600245A1

公开(公告)日：2020-02-05

申请号：EP18715946.2

申请日：2018-03-29

申请人： The University of Liverpool ,  The Johns Hopkins University

发明人： RANNARD, Steven Paul ,  OWEN, Andrew ,  CURLEY, Paul ,  HOBSON, James ,  SICCARDI, Marco ,  FREEL MEYERS, Caren L. ,  AL-KHOUJA, Amer ,  MEYERS, David J. ,  FLEXNER, Charles Williams

IPC分类号： A61K9/00 ,  A61K47/14 ,  A61K9/08 ,  A61K47/44 ,  A61K9/14 ,  A61K9/19 ,  A61K9/48 ,  A61K31/675

公开(公告)号：EP4408389A1

公开(公告)日：2024-08-07

申请号：EP22786406.3

申请日：2022-09-29

申请人： The University Of Liverpool

发明人： RANNARD, Steven Paul ,  OWEN, Andrew ,  DWYER, Andrew ,  UNSWORTH, Catherine ,  HOBSON, James ,  CURLEY, Paul ,  SHARP, Joanne ,  DONNELLY, Ryan ,  NASER, Yara

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/70

CPC分类号： A61K9/0021 ,  A61K9/0019 ,  A61K9/19 ,  A61K9/1635 ,  A61K9/0024 ,  A61K9/70 ,  A61K31/4985 ,  A61K31/454

公开(公告)号：EP4243777A1

公开(公告)日：2023-09-20

申请号：EP21815584.4

申请日：2021-11-10

申请人： The University of Liverpool

发明人： RANNARD, Steven Paul ,  OWEN, Andrew ,  HOBSON, James ,  SAVAGE, Alison ,  DWYER, Andrew ,  UNSWORTH, Catherine ,  MCDONALD, Thomas Oliver

IPC分类号： A61K9/14 ,  A61K9/16

公开(公告)号：EP4419073A1

公开(公告)日：2024-08-28

申请号：EP22797827.7

申请日：2022-10-20

申请人： The University Of Liverpool

发明人： RANNARD, Steven Paul ,  OWEN, Andrew ,  HOBSON, James ,  SAVAGE, Alison ,  BARLOW, Eleanor ,  CURLEY, Paul ,  SHARP, Joanne ,  DONNELLY, Ryan ,  ZHANG, Chunyang ,  WU, Yu

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/00 ,  A61P31/00

CPC分类号： A61K9/0021 ,  A61K9/0024 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/1623 ,  A61K9/1617 ,  A61K9/0019 ,  A61P31/00 ,  A61K31/675 ,  A61K31/553

公开(公告)号：EP3253371A1

公开(公告)日：2017-12-13

申请号：EP16703830.6

申请日：2016-02-03

申请人： The University of Liverpool

发明人： RANNARD, Steve ,  OWEN, Andrew ,  HOBSON, James ,  LIPTROTT, Neill ,  CHAMBON, Pierre

IPC分类号： A61K9/107 ,  A61K47/10 ,  A61K47/34 ,  C08F220/20

CPC分类号： A61K9/1641 ,  A61K9/0053 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/513 ,  A61K31/536 ,  A61K47/10 ,  A61K47/34 ,  B01F17/0028 ,  C08F220/28 ,  C08F2220/286 ,  C08F2438/01 ,  C08F2222/1013

摘要： An oil-in-water emulsion comprises an emulsifier which is a non-gelled branched polymer (e.g. a branched vinyl polymer), wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. This is useful in, for example, facilitating the carrying of hydrophobic materials within aqueous systems, to enhance oral drug delivery. The oil-in-water emulsion may be prepared by mixing an oil phase with an aqueous phase in the presence of an emulsifier, wherein said emulsifier is a non-gelled branched polymer, wherein the ends of at least some of the chains of said polymer terminate in an alkyl chain of 5 carbon atoms or more, and wherein the oil-in-water emulsion takes the form of particles having a z-average diameter of no greater than about 1000 nm. The oil phase may comprise a further solvent which is miscible with the oil, said solvent being allowed to evaporate to produce the final emulsion.