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公开(公告)号：EP2734547A1
公开(公告)日：2014-05-28
申请号：EP12735555.0
申请日：2012-07-17
IPC分类号： C07K16/24 , A61P19/02 , A61P25/04 , A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/243 , C07K16/244 , C07K16/249 , C07K2317/76
摘要： The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.
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公开(公告)号：EP2734547B1
公开(公告)日：2016-12-21
申请号：EP12735555.0
申请日：2012-07-17
CPC分类号： C07K16/2866 , A61K2039/505 , C07K16/243 , C07K16/244 , C07K16/249 , C07K2317/76
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公开(公告)号：EP2387418B1
公开(公告)日：2018-06-13
申请号：EP09833923.7
申请日：2009-12-21
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/243 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
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公开(公告)号：EP2376121B1
公开(公告)日：2016-03-09
申请号：EP09833924.5
申请日：2009-12-21
IPC分类号： A61K39/395 , A61P19/02 , C07K16/28
CPC分类号： C07K16/2866 , A61K39/395 , A61K2039/505 , C07K16/243 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to an antagonist of GM-CSF for use in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor. The present invention also relates to the use of an antagonist of GM-CSF in the preparation of a medicament in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor as well as to compositions comprising said antagonist of GM-CSF for use in the treatment of osteoarthritis.
摘要翻译： 本发明涉及用于治疗骨关节炎的GM-CSF拮抗剂，其中拮抗剂是对GM-CSF受体特异的抗体。 本发明还涉及GM-CSF拮抗剂在制备用于治疗骨关节炎的药物中的用途，其中所述拮抗剂是对GM-CSF受体特异性的抗体以及包含所述GM的拮抗剂的组合物 -CSF用于治疗骨关节炎。
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公开(公告)号：EP3381471A1
公开(公告)日：2018-10-03
申请号：EP18170226.7
申请日：2009-12-21
IPC分类号： A61K39/395 , A61P29/00 , C07K16/24 , A61K39/00 , C07K16/28
CPC分类号： C07K16/243 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to antagonists of GM-CSF for use in the treatment of osteoarthritic pain in a subject, wherein said antagonist is an antibody specific for GM-CSF or an antibody specific for the GM-CSF receptor; and to compositions comprising said antagonists of GM-CSF for said use.
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公开(公告)号：EP3056217A1
公开(公告)日：2016-08-17
申请号：EP15194091.3
申请日：2009-12-21
IPC分类号： A61K39/395 , C07K16/28 , A61P19/02
CPC分类号： C07K16/2866 , A61K39/395 , A61K2039/505 , C07K16/243 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to an antagonist of GM-CSF for use in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor. The present invention also relates to the use of an antagonist of GM-CSF in the preparation of a medicament in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor as well as to compositions comprising said antagonist of GM-CSF for use in the treatment of osteoarthritis.
摘要翻译： 本发明涉及用于治疗骨关节炎的GM-CSF拮抗剂，其中所述拮抗剂是对GM-CSF受体具有特异性的抗体。 本发明还涉及GM-CSF拮抗剂在制备用于治疗骨关节炎的药物中的用途，其中所述拮抗剂是对GM-CSF受体特异性的抗体以及包含所述GM拮抗剂的组合物 -CSF用于治疗骨关节炎。
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公开(公告)号：EP2387418A1
公开(公告)日：2011-11-23
申请号：EP09833923.7
申请日：2009-12-21
IPC分类号： A61K39/395 , A61P29/00
CPC分类号： C07K16/243 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
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公开(公告)号：EP2376121A1
公开(公告)日：2011-10-19
申请号：EP09833924.5
申请日：2009-12-21
IPC分类号： A61K39/395 , A61P19/02
CPC分类号： C07K16/2866 , A61K39/395 , A61K2039/505 , C07K16/243 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to an antagonist of GM-CSF for use in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor. The present invention also relates to the use of an antagonist of GM-CSF in the preparation of a medicament in the treatment of osteoarthritis, wherein the antagonist is an antibody specific for the GM-CSF receptor as well as to compositions comprising said antagonist of GM-CSF for use in the treatment of osteoarthritis.
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