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公开(公告)号：EP2926830B1
公开(公告)日：2017-08-02
申请号：EP14004015.5
申请日：2011-08-31
申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International Aids Vaccine Initiative
发明人： CHAN-HUI, Po-Ying , DOORES, Katherine , HUBER, Michael , KAMINSKY, Stephen , FREY, Steven , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , PHOGAT, Sanjay K. , BURTON, Dennis R. , WALKER, Laura Marjorie , POIGNARD, Pascal Raymond Georges , KOFF, Wayne , SIMEK-LEMOS, Melissa Danielle ...
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
摘要翻译： 本发明提供了获得广泛中和抗体（bNab）的方法，包括筛选来自供体PBMC样品的记忆B细胞培养物的针对多种HIV-1物种的中和活性，克隆展现广泛中和活性的记忆B细胞; 并从该记忆B细胞培养物中拯救单克隆抗体。 得到的单克隆抗体的特征可在于其以天然或单体形式选择性结合Env蛋白的表位的能力，以及抑制来自多个进化枝的HIV-1物种的感染。 提供了含有用于预防，诊断和治疗HIV感染的人单克隆抗HIV抗体的组合物。 提供了使用来自gp120的可变环内的保守区的表位进行免疫来产生此类抗体的方法。 还提供了用于产生抗HIV1bNAb的免疫原。 此外，提供了使用合适表位的疫苗接种方法。
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公开(公告)号：EP2611465A2
公开(公告)日：2013-07-10
申请号：EP11822530.9
申请日：2011-08-31
申请人： Theraclone Sciences, Inc. , The Scripps Research Institute , International Aids Vaccine Initiative
发明人： CHAN-HUI, Po-ying , DOORES, Katherine , HUBER, Michael , KAMINSKY, Stephen , FREY, Steven , OLSEN, Ole , MITCHAM, Jennifer , MOYLE, Matthew , PHOGAT, Sanjay K. , BURTON, Dennis R. , WALKER, Laura Marjorie , POIGNARD, Pascal Raymond Georges , KOFF, Wayne , SIMEK-LEMOS, Melissa Danielle, de Jean de St. Marcel
CPC分类号： C07K16/1063 , A61K39/21 , A61K2039/505 , C07K16/1045 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
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公开(公告)号：EP4001304A1
公开(公告)日：2022-05-25
申请号：EP21207691.3
申请日：2015-06-10
发明人： BURTON, Dennis R. , VAN GILS, J. Marit , KOFF, Wayne , POIGNARD, Pascal Raymond Georges , SANDERS, Rogier W. , SIMEK-LEMOS, D.J.S. Melissa
IPC分类号： C07K16/10
摘要： The present invention relates to an exceptionally broad and potent neutralizing anti-HIV-1 monoclonal antibody which may comprise cross-clade neutralizing coverage of 83% at a median IC 50 of 0.003 µg/ml, compositions containing the same and uses thereof.
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公开(公告)号：EP2618843B1
公开(公告)日：2016-12-07
申请号：EP11827599.9
申请日：2011-09-23
申请人： International Aids Vaccine Initiative , The Scripps Research Institute , National Institutes Of Health
发明人： MASCOLA, John , BURTON, Dennis R. , KOFF, Wayne , KWONG, Peter , NABEL, Gary , PHOGAT, Sanjay K. , POIGNARD, Pascal Raymond Georges , SIMEK-LEMOS, Melissa Danielle De Jean De St. Marcel , WU, Xueling , YANG, Zhi-Yong , ZHOU, Tongqing
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/56988
摘要： The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.
摘要翻译： 本申请涉及针对HIV-1的广泛中和单克隆抗体。 特别地，公开了单克隆抗体VRC-PG04和VRC-PG05。
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公开(公告)号：EP2618843A2
公开(公告)日：2013-07-31
申请号：EP11827599.9
申请日：2011-09-23
申请人： International Aids Vaccine Initiative , The Scripps Research Institute , National Institutes Of Health
发明人： MASCOLA, John , BURTON, Dennis R. , KOFF, Wayne , KWONG, Peter , NABEL, Gary , PHOGAT, Sanjay K. , POIGNARD, Pascal Raymond Georges , SIMEK-LEMOS, Melissa Danielle De Jean De St. Marcel , WU, Xueling , YANG, Zhi-Yong , ZHOU, Tongqing
IPC分类号： A61K39/42
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/56988
摘要： The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.
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6.发明公开HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS 失效人文中和AGAINST THE RISE免疫缺陷病毒的单克隆抗体从人。
公开(公告)号：EP0675904A1
公开(公告)日：1995-10-11
申请号：EP93923749.0
申请日：1993-09-30
IPC分类号： C07K , G01N33 , A61K39 , A61K49 , A61K51 , A61P31 , C07K16 , C12N15 , C12P21 , A61K38 , C12R1
CPC分类号： C07K16/1063 , A61K38/00 , A61K49/16 , A61K51/10 , C07K16/40 , C07K2317/55 , C07K2319/035 , C07K2319/40
摘要： The present invention describes human monoclonal antibodies which immunoreact with and neutralize human immunodeficiency virus (HIV). Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell line for producing the monoclonal antibodies.
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7.发明授权
公开(公告)号：EP0724651B1
公开(公告)日：2008-08-20
申请号：EP94931922.2
申请日：1994-10-19
CPC分类号： C07K16/1063 , A61K49/00 , C07K2319/00 , G01N33/56988 , Y10S435/975
摘要： The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
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8.发明公开METHOD FOR IDENTIFYING PROTECTIVE ANTIGENS FOR ELICITING NEUTRALIZING ANTIBODIES 失效法的保护性抗原中和抗体鉴定中TRACKING
公开(公告)号：EP0787211A1
公开(公告)日：1997-08-06
申请号：EP95939994.0
申请日：1995-11-13
CPC分类号： G01N33/56983 , C07K16/081 , C07K16/1063
摘要： The present invention provides a novel method for the identification of antigens which may be useful for inducing neutralizing antibodies. The method is based on the use of antigens as solid phase capture reagents to bind to a population of antibodies from a subject having an infection and high neutralizing serum titers through the period of natural infection. The method is particularly suited for screening libraries of cloned antibodies, such as phage display combinatorial antibodies.
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9.发明公开
公开(公告)号：EP0724651A1
公开(公告)日：1996-08-07
申请号：EP94931922.0
申请日：1994-10-19
CPC分类号： C07K16/1063 , A61K49/00 , C07K2319/00 , G01N33/56988 , Y10S435/975
摘要： The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
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10.发明授权HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS 失效人体中和抗体免疫缺陷单克隆人强调了环端部VIRUS
公开(公告)号：EP0675904B1
公开(公告)日：2003-03-05
申请号：EP93923749.1
申请日：1993-09-30
IPC分类号： C12N15/13 , A61K39/395 , G01N33/569
CPC分类号： C07K16/1063 , A61K38/00 , A61K49/16 , A61K51/10 , C07K16/40 , C07K2317/55 , C07K2319/035 , C07K2319/40
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