公开(公告)号：EP2230907A1

公开(公告)日：2010-09-29

申请号：EP08859426.2

申请日：2008-12-11

申请人： Theracos, Inc.

发明人： CHEN, Yuanwei ,  PENG, Kun ,  ZHANG, Lili ,  LV, Binhua ,  XU, Baihua ,  DONG, Jiajia ,  DU, Jiyan ,  FENG, Yan ,  XU, Ge ,  RAJAPPAN, Vasanthakumar ,  SEED, Brian

IPC分类号： A01N31/04

CPC分类号： C07H7/04

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

摘要翻译： 提供了对钠依赖性葡萄糖协同转运蛋白SGLT具有抑制作用的化合物。 本发明还提供了药物组合物，制备该化合物的方法，合成中间体以及独立地或与其他治疗剂组合使用该化合物用于治疗受SGLT抑制影响的疾病和病症的方法。

公开(公告)号：EP2187742A1

公开(公告)日：2010-05-26

申请号：EP08798514.9

申请日：2008-08-22

申请人： Theracos, Inc.

发明人： SONG, Yanli ,  CHEN, Yuanwei ,  CHENG, Huawei ,  LI, Shengbin ,  WU, Yuelin ,  FENG, Yan ,  LV, Binhua ,  XU, Baihua ,  SEED, Brian ,  HADD, Michael J. ,  DU, Jiyan ,  WANG, Congna ,  ROBERGE, Jacques Y.

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： C07H7/04 ,  C07D309/10 ,  C07D407/12

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

摘要翻译： 提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。 本发明还提供药物组合物，制备化合物的方法，合成中间体以及独立地或与其它治疗剂组合使用化合物用于治疗受SGLT抑制影响的疾病和病症的方法。

公开(公告)号：EP2230907B1

公开(公告)日：2018-05-09

申请号：EP08859426.2

申请日：2008-12-11

申请人： Theracos, Inc.

发明人： CHEN, Yuanwei ,  PENG, Kun ,  ZHANG, Lili ,  LV, Binhua ,  XU, Baihua ,  DONG, Jiajia ,  DU, Jiyan ,  FENG, Yan ,  XU, Ge ,  RAJAPPAN, Vasanthakumar ,  SEED, Brian

IPC分类号： C07C13/28 ,  C07C25/10 ,  C07C35/21 ,  C07C43/23 ,  C07C43/235 ,  C07C49/303 ,  C07C49/403 ,  C07C49/497 ,  C07C62/04 ,  A61K31/015 ,  A61K31/045 ,  A61K31/085 ,  A61P3/04

CPC分类号： C07H7/04

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

公开(公告)号：EP2064222A1

公开(公告)日：2009-06-03

申请号：EP08744883.3

申请日：2008-04-01

申请人： Theracos, Inc.

发明人： CHEN, Yuanwei ,  FENG, Yan ,  XU, Baihua ,  LV, Binhua ,  SEED, Brian ,  HADD, Michael J. ,  CHENG, Huawei ,  SHENG, Zelin ,  XU, Min ,  WANG, Congna ,  DU, Jiyan ,  ZHANG, Lili ,  XU, Ge ,  WU, Yuelin

IPC分类号： C07G3/00

CPC分类号： C07H7/04 ,  A61K38/00 ,  C07D309/10

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

公开(公告)号：EP2312944B1

公开(公告)日：2018-09-05

申请号：EP09798706.9

申请日：2009-07-15

申请人： Theracos, Inc.

发明人： SEED, Brian ,  LV, Binhua ,  ROBERGE, Jacques, Y. ,  CHEN, Yuanwei ,  PENG, Kun ,  DONG, Jiajia ,  XU, Baihua ,  DU, Jiyan ,  ZHANG, Lili ,  TANG, Xinxing ,  XU, Ge ,  FENG, Yan ,  XU, Min

IPC分类号： A01N43/04 ,  C07H7/04

CPC分类号： A61K45/06 ,  A61K31/35 ,  C07D309/10 ,  A61K2300/00

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.

公开(公告)号：EP2064222B1

公开(公告)日：2014-05-07

申请号：EP08744883.3

申请日：2008-04-01

申请人： Theracos, Inc.

发明人： CHEN, Yuanwei ,  FENG, Yan ,  XU, Baihua ,  LV, Binhua ,  SEED, Brian ,  HADD, Michael J. ,  CHENG, Huawei ,  SHENG, Zelin ,  XU, Min ,  WANG, Congna ,  DU, Jiyan ,  ZHANG, Lili ,  XU, Ge ,  WU, Yuelin

IPC分类号： C07D309/10

CPC分类号： C07H7/04 ,  A61K38/00 ,  C07D309/10

公开(公告)号：EP2312944A1

公开(公告)日：2011-04-27

申请号：EP09798706.9

申请日：2009-07-15

申请人： Theracos, Inc.

发明人： SEED, Brian ,  LV, Binhua ,  ROBERGE, Jacques, Y. ,  CHEN, Yuanwei ,  PENG, Kun ,  DONG, Jiajia ,  XU, Baihua ,  DU, Jiyan ,  ZHANG, Lili ,  TANG, Xinxing ,  XU, Ge ,  FENG, Yan ,  XU, Min

IPC分类号： A01N43/04

CPC分类号： A61K45/06 ,  A61K31/35 ,  C07D309/10 ,  A61K2300/00

摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by SGLT inhibition.