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公开(公告)号：EP2861233A1
公开(公告)日：2015-04-22
申请号：EP13807463.8
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
发明人： BERNICK, Brian A. , AMADIO, Julia M. , PERSICANER, Peter H.R. , CACACE, Janice Louise , IRANI, Neda
IPC分类号： A61K31/56
摘要： Hormone replacement therapies are provided comprising solubilized progesterone alone and optionally with an estrogen, cyclic/sequential and continuous-combined dosing, and administered via transdermal HRT delivery systems.
摘要翻译： 提供了激素替代疗法，其包含单独的溶解黄体酮和任选地与雌激素，环状/连续和连续联合给药，并且经由透皮HRT递送系统给药。
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公开(公告)号：EP3909586A1
公开(公告)日：2021-11-17
申请号：EP21167943.6
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
发明人： AMADIO, Julia M. , BERNICK, Brian A. , CACACE, Janice Louise , IRANI, Neda , PERSICANER, Peter H. R. , THORSTEINSSON, Thorsteinn
摘要： According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：EP2861234A1
公开(公告)日：2015-04-22
申请号：EP13807121.2
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
CPC分类号： A61K47/14 , A61K9/0014 , A61K9/1075 , A61K9/48 , A61K9/4825 , A61K31/565 , A61K31/566 , A61K31/57 , A61K31/573 , A61K45/06 , A61K47/10 , A61K2300/00
摘要： Hormone replacement therapies are provided comprising solubilized progesterone alone and optionally with an estrogen, cyclic/sequential and continuous-combined dosing, and administered via transdermal HRT delivery systems.
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公开(公告)号：EP2861233B1
公开(公告)日：2019-11-06
申请号：EP13807463.8
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
发明人： BERNICK, Brian A. , AMADIO, Julia M. , PERSICANER, Peter H.R. , CACACE, Janice Louise , IRANI, Neda
IPC分类号： A61K9/70 , A61K31/57 , A61K31/565 , A61K47/14 , A61K45/06
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6.发明公开VAGINAL INSERTED ESTRADIOL PHARMACEUTICAL COMPOSITONS AND METHODS 审中-公开阴道进口药品ÖSTRADIOLZUSAMMENSETZUNGEN和程序
公开(公告)号：EP3060179A1
公开(公告)日：2016-08-31
申请号：EP14862905.8
申请日：2014-10-22
申请人： Therapeuticsmd, Inc.
发明人： BERNICK, Brian A. , THORSTEINSSON, Thorsteinn , PERSICANER, Peter H. R. , CACACE, Janice Louise , AMADIO, Julia M. , SANSCILIO, Frederick D. , IRANI, Neda
IPC分类号： A61F6/06 , A61K31/565 , A61K9/00
CPC分类号： A61K9/4875 , A61K9/0034 , A61K31/565
摘要： According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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公开(公告)号：EP4309646A1
公开(公告)日：2024-01-24
申请号：EP23198869.2
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
发明人： BERNICK, Brian A , CACACE, Janice Louise , PERSICANER, Peter H.R , IRANI, Neda , AMADIO, Julia M , SANCILIO, Frederick D
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：EP3936133A1
公开(公告)日：2022-01-12
申请号：EP21177701.6
申请日：2012-11-21
申请人： TherapeuticsMD, Inc.
发明人： AMADIO, Julia M. , BERNICK, Brian A. , CACACE, Janice Louise , IRANI, Neda , PERSICANER, Peter H. R. , SANCILIO, Frederick D.
摘要： Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.
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公开(公告)号：EP3560500A1
公开(公告)日：2019-10-30
申请号：EP19163006.0
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
摘要： Pharmaceutical formulations for oral use in hormone replacement therapy comprising ultra-micronized progesterone are disclosed, wherein the ultra-micronized progesterone is combined with a suitable excipient. The preferred excipients comprise medium chain fatty acid-glycol esters and a nonionic surfactant comprising a polyethylene glycol fatty acid ester. In some embodiments C8 to C18 fatty acid esters of glycerol and polyethylene glycol are the preferred nonionic surfactants.
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公开(公告)号：EP2861073A1
公开(公告)日：2015-04-22
申请号：EP13807188.1
申请日：2013-06-18
申请人： TherapeuticsMD, Inc.
发明人： BERNICK, Brian A. , AMADIO, Julia M. , PERSICANER, Peter H. R. , THORSTEINSSON, Thorsteinn , CACACE, Janice Louise
IPC分类号： A01N45/00
CPC分类号： A61K9/0034 , A61K9/02 , A61K9/06 , A61K9/48 , A61K31/565 , A61K47/14 , A61K47/42
摘要： According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.
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