公开(公告)号：EP2951209A1

公开(公告)日：2015-12-09

申请号：EP14745477.1

申请日：2014-01-31

申请人： Thomas Jefferson University

发明人： TYKOCINSKI, Mark, L. ,  WEBER, Matthew, Charles

IPC分类号： C07K19/00

CPC分类号： C07K16/2878 ,  A61K39/3955 ,  C07K14/70575 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2319/00

摘要： Members of the TNF ligand/ TNF receptor superfamily play key roles in a large number of biological events. For instance, members of the TNF ligand/TNF receptor superfamily figure prominently in the complex interplay of positive and negative signals that regulate T cell activation, maintenance of T cell effector function, promotion of maturation of antigen-presenting cells, such as dendritic cells, and the T cell stimulation of APCs. TNF receptors are broadly classified in three groups Receptors in the first group contain a death domain in their cytoplasmic tails. Receptors in the second group contain a TRAF interaction motif in their cytoplasmic tails. The third group of TNF receptors do not contain functional intracellular signaling domains but can act as decoy receptors.