公开(公告)号：EP3134203B1

公开(公告)日：2018-04-04

申请号：EP15774672.8

申请日：2015-09-28

申请人： Thomas Swan and Co. Ltd.

发明人： DUNN, David ,  SUTTON, Howard Winston Tyrrell ,  DALY, John Ing Chuan ,  GRANT, Simon Jonathon ,  HUTCHINGS, Lian ,  RIBIERE, Patrice Georges Antonin ,  GIBBINGS, Matthew Richard ,  GAMBOA MARTINEZ, Sergio Aaron ,  ANDERSON, Craig ,  ROGAN, Yulia

IPC分类号： B01J23/58 ,  C07D307/06 ,  C07D307/12

CPC分类号： C07D307/12 ,  B01J23/58

摘要： A hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support, is used in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst.

公开(公告)号：EP3134203A1

公开(公告)日：2017-03-01

申请号：EP15774672.8

申请日：2015-09-28

申请人： Thomas Swan and Co. Ltd.

发明人： DUNN, David ,  SUTTON, Howard Winston Tyrrell ,  DALY, John Ing Chuan ,  GRANT, Simon Jonathon ,  HUTCHINGS, Lian ,  RIBIERE, Patrice Georges Antonin ,  GIBBINGS, Matthew Richard ,  GAMBOA MARTINEZ, Sergio Aaron ,  ANDERSON, Craig ,  ROGAN, Yulia

IPC分类号： B01J23/58 ,  C07D307/06

CPC分类号： C07D307/12 ,  B01J23/58

摘要： A hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support, is used in the presence of lithium salts, with salts such as the borates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselective bias in the product of alkene hydrogenation using the catalyst.

摘要翻译： 一种立体选择性氢化的方法，包括提供下式的底物：其中Cyc1表示不饱和部分为五或六元杂环，杂原子是O，S，N或P之一; R1代表氢或非手性有机化学基团; 催化剂组合物包含：在锂盐存在下在载体上的金属氢化催化剂。 底物可以是1,2-二（2-呋喃基）丙烷，并且可以以超过52％的内消旋异构体存在。 金属氢化催化剂是铂，钯，钌，铑或镍中的一种或多种。 载体选自碳，氧化铝，二氧化硅，二氧化钛，碳酸钙，铝酸锂和硫酸钡。 锂盐可以是四硼酸锂，偏硼酸锂或它们的水合物。