公开(公告)号：EP1648467A1

公开(公告)日：2006-04-26

申请号：EP04766264.8

申请日：2004-07-19

申请人： Tibotec Pharmaceuticals Ltd.

发明人： LAMOUREUX, Gaël ,  COUSIN, Gérard ,  THONÉ , Daniel, Joseph, Christiaan

IPC分类号： A61K31/53 ,  A61P31/18 ,  A61K9/16 ,  A61K9/50

CPC分类号： A61K31/505 ,  A61K9/1676 ,  A61K9/1682 ,  A61K9/5078 ,  A61K9/5089 ,  A61K31/4196 ,  A61K31/53

摘要： A process for preparing a particle comprising a co-precipitate surrounding a neutral hydrophilic carrier, said process comprising spraying an organic solution on a neutral hydrophilic carrier, said solution comprising at least one triazine or pyrimidine active ingredient having HIV inhibiting properties, one surface active agent, and one hydrophilic polymer, wherein the spraying of whole of the solution occurs in at least two separate steps, each of these steps followed by a grinding step of the product obtained at the end of the preceding step.

摘要翻译： 一种用于制备颗粒，其包含周围的中性亲水性载体的共沉淀方法，所述方法的中性亲水性载体上的包含有机溶液的喷雾，所述溶液包含至少一种三嗪或嘧啶的活性成分具有HIV抑制特性，一种表面活性剂 和一种亲水性聚合物，worin整体在溶液的喷洒发生在至少两个分开的步骤中，每个随后在preceding-步骤结束时获得的产物的研磨步骤的合成步骤。