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公开(公告)号：EP1667675A1
公开(公告)日：2006-06-14
申请号：EP04766768.8
申请日：2004-09-10
发明人： VAN ACKER, Koenraad, Lodewijk, August , WIGERINCK, Piet, Tom, Bert, Paul , MICHIELS, Lieve, Emma, Jan , TAHRI, Abdellah
IPC分类号： A61K31/34 , A61K31/472 , C07D307/68 , C07D217/02 , C07D403/14 , C07D207/06 , C07D215/24
CPC分类号： C07C233/29 , C07C233/73 , C07C233/75 , C07C235/16 , C07C235/24 , C07C235/56 , C07C237/04 , C07C311/21 , C07C311/29 , C07D207/06 , C07D215/08 , C07D217/02 , C07D217/06 , C07D295/13 , C07D295/15 , C07D307/68 , C07D317/68 , C07D405/12 , C07D405/14
摘要： The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS. The compounds of formula (I) have the following structure: (I).
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2.发明授权(1,10B-DIHYDRO-2-(AMINOCARBONYL-PHENYL)-5H-PYRAZOLO[1,5- C][1,3]BENZOXAZIN-5-YL)PHENYL METHANONE DERIVATIVES AS HIV VIRAL REPLICATION INHIBITORS 有权（1,10B二氢-2-（氨基羰基）-5H-吡唑并[1,5-C] [1,3]苯并恶嗪-5-基）PHENYLMETHANONDERIVATE AS病毒复制HIV的抑制剂
公开(公告)号：EP1778696B1
公开(公告)日：2008-03-19
申请号：EP05740229.9
申请日：2005-05-04
发明人： TAHRI, Abdellah , MICHIELS, Lieve, Emma, Jan , VAN ACKER, Koenraad, Lodewijk, August , SURLERAUX, Dominique, Louis, Nestor, Ghislain
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： A61K31/538 , C07D498/04
摘要： The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
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公开(公告)号：EP1670937A1
公开(公告)日：2006-06-21
申请号：EP04787179.3
申请日：2004-09-20
发明人： VAN ACKER, Koenraad, Lodewijk, August , BUNKENS, Lieve, Elisabeth, Louis , DAMS, Géry, Karel, Julia , HERTOGS, Kurt , IVENS, Tania, Pauline, Eduard , NIJS, Erik, Jos, Amandus
IPC分类号： C12Q1/18
CPC分类号： C12Q1/701 , C12Q1/18 , G01N33/56988 , G01N2500/10
摘要： The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an assay according to the invention and pharmaceutical compositions comprising a therapeutically effective amount of such compounds. The identified compounds may be used as medicaments, and in particular for the manufacture of a medicament for treating infectious diseases and in method for treating infectious diseases including AIDS.
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4.发明公开(1,10B-DIHYDRO-2-(AMINOCARBONYL-PHENYL)-5H-PYRAZOLO[1,5- C][1,3]BENZOXAZIN-5-YL)PHENYL METHANONE DERIVATIVES AS HIV VIRAL REPLICATION INHIBITORS 有权（1,10B二氢-2-（氨基羰基）-5H-吡唑并[1,5-C] [1,3]苯并恶嗪-5-基）PHENYLMETHANONDERIVATE AS病毒复制HIV的抑制剂
公开(公告)号：EP1778696A2
公开(公告)日：2007-05-02
申请号：EP05740229.9
申请日：2005-05-04
发明人： TAHRI, Abdellah , MICHIELS, Lieve, Emma, Jan , VAN ACKER, Koenraad, Lodewijk, August , SURLERAUX, Dominique, Louis, Nestor, Ghislain
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： A61K31/538 , C07D498/04
摘要： The present invention realtes to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present HIV inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
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