公开(公告)号：EP1458447B1

公开(公告)日：2009-09-09

申请号：EP02793018.9

申请日：2002-12-12

申请人： Tibotec Pharmaceuticals Ltd.

发明人： VAN DER GEEST, Ronald ,  STOFFELS, Paul ,  GROEN, Cornelis ,  JOCHMANS, Dirk, Edward, Désiré

IPC分类号： A61P31/18 ,  A61K31/365 ,  A61K31/635 ,  A61K31/425 ,  A61K31/435 ,  A61K31/47 ,  A61K31/495 ,  A61K45/06

CPC分类号： A61K31/635 ,  A61K2300/00

摘要： The present invention relates to a method for improving the pharmacokinetics of hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitors comprising administering to a human in need thereof a combination of a therapeutically effective amount of a hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitor, and a therapeutically effective amount of a cytochrom P450 inhibitor.

公开(公告)号：EP1458447A2

公开(公告)日：2004-09-22

申请号：EP02793018.9

申请日：2002-12-12

申请人： Tibotec Pharmaceuticals Ltd.

发明人： VAN DER GEEST, Ronald ,  STOFFELS, Paul ,  GROEN, Cornelis ,  JOCHMANS, Dirk, Edward, Désiré

IPC分类号： A61P31/18 ,  A61K31/365

CPC分类号： A61K31/635 ,  A61K2300/00

摘要： The present invention relates to a method for improving the pharmacokinetics of hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitors comprising administering to a human in need thereof a combination of a therapeutically effective amount of a hexahydrofuro[2,3-b]furanyl containing HIV protease inhibitor, and a therapeutically effective amount of a cytochrom P450 inhibitor.