公开(公告)号：EP4249462A1

公开(公告)日：2023-09-27

申请号：EP21894338.9

申请日：2021-10-01

申请人： Tokuyama Corporation ,  OSAKA UNIVERSITY

发明人： SEKI Masahiko ,  MASHIMA Kazushi ,  TSURUGI Hayato ,  KATO Daiki ,  MURASE Tomoya ,  TALODE Jalindar Bhausaheb

IPC分类号： C07C45/61 ,  C07D333/22 ,  C07C49/784 ,  C07C49/84 ,  C07D295/192 ,  C07C67/28 ,  C07C69/157

摘要： An object of the present invention is to provide a novel method for producing a ketone derivative, and more specifically, a method for producing a ketone derivative (I) represented by formula (I), including mixing a thioester derivative (II) represented by formula (II), a Grignard reagent (III) represented by formula (III) and a copper salt to form a ketone derivative (I).

公开(公告)号：EP4353728A1

公开(公告)日：2024-04-17

申请号：EP22820346.9

申请日：2022-06-10

申请人： Tokuyama Corporation

发明人： SEKI Masahiko ,  MASHIMA Kazushi ,  TSURUGI Hayato ,  KATO Daiki

IPC分类号： C07D495/04 ,  C07B61/00

CPC分类号： C07D495/04 ,  C07B61/00

摘要： It is an object to provide a high-yield production method of a hydroxythienoimidazole derivative, a vinyl sulfide derivative, an n-butylidene sulfide derivative, and a thienoimidazole derivative substituted with a straight-chain saturated hydrocarbon, and, in order to achieve the object, a production method according to one embodiment includes a step of mixing a thiolactone derivative represented by formula (I) with a Grignard reagent represented by formula (1) or (2) in the presence of a copper salt to obtain a hydroxythienoimidazole derivative represented by formula (II) or (IV).