公开(公告)号：EP1859676A1

公开(公告)日：2007-11-28

申请号：EP06713731.5

申请日：2006-02-08

申请人： Tokyo Metropolitan Organization for Medical Research ,  National University Corporation Nara Institute of Science and Technology

发明人： YONEKAWA, Hiromichi ,  TAKADA, Toyoyuki ,  SHITARA, Hiroshi ,  KIKKAWA, Yoshiaki ,  ISHII, Rie ,  KOHNO, K, NAT. UNIVERSITY CORP. NARA INST. SC.&TEC

IPC分类号： A01K67/027 ,  C12N15/09 ,  G01N33/15 ,  G01N33/50 ,  C12N5/10

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/485

摘要： The present invention provides a hairless transgenic nonhuman animal used in the development of a therapy for dermatitis such as human atopic dermatitis and drug discovery. Specifically, the present invention provides a transgenic nonhuman animal, into which recombinant DNA comprising a heparin-binding EGF gene and a type 2 keratin gene promoter for regulating expression of the above gene has been introduced.

摘要翻译： 本发明提供了用于开发诸如人特应性皮炎和药物发现的皮炎治疗的无毛转基因非人动物。 具体地，本发明提供了一种转基因非人动物，其中引入了包含肝素结合EGF基因的重组DNA和用于调节上述基因表达的2型角蛋白基因启动子。