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1.发明公开NUCLEIC ACID CONSTRUCT CONTAINING FULL-LENGTH GENOME OF HUMAN HEPATITIS C VIRUS, RECOMBINANT FULL-LENGTH VIRUS GENOME REPLICATIVE CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO AND METHOD OF CONSTRUCTING HEPATITIS C VIRAL PARTICLES 有权与VOLLÄNGENGENOM人丙型肝炎病毒，重组病毒基因组全长滚动细胞透过您在施工丙型肝炎病毒颗粒传送核构建和方法的核构建
公开(公告)号：EP1721985A1
公开(公告)日：2006-11-15
申请号：EP05719575.2
申请日：2005-02-21
发明人： WAKITA, Takaji , KATO, Takanobu; , DATE, Tomoko; , MIYAMOTO, Michiko; , TANABE, Jun-ichi , SONE, Saburo;
IPC分类号： C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/01 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/567 , C07K16/08 , A61K35/76 , A61P37/04
CPC分类号： C12N7/00 , A61K2039/525 , C07K16/109 , C12N15/86 , C12N2770/24221 , C12N2770/24243 , C12N2840/203 , G01N33/5767
摘要： The present invention provides a method for replicating efficiently an RNA containing fulllength HCV genomic sequence and a method for producing HCV virus particles containing fulllength HCV replicon RNA or fulllength HCV genomic RNA by using a cell culture system. Further, the present invention relates to a method for producing hepatitis C virus particles which comprises culturing a cell, into which a replicon RNA comprising a nucleotide sequence comprising a fulllength genomic RNA sequence of hepatitis C virus of the genotype 2a, at least one selectable marker gene and/or at least one reporter gene and at least one IRES sequence or the fulllength genomic RNA of hepatitis C virus of the genotype 2a is introduced, and generating virus particles in the culture medium. Still further the present invention relates also to a hepatitis C vaccine and an antibody against hepatitis C virus particles.
摘要翻译： 本发明提供了一种用于有效地复制到RNA含有全长HCV基因组序列和用于产生通过使用细胞培养系统含有全长HCV复制子RNA或全长HCV基因组RNA的HCV病毒颗粒的方法。此外，本发明涉及一种方法 对于一种用于生产包括培养细胞，丙型肝炎病毒颗粒进入哪一个复制子RNA包含的核苷酸序列，其包含基因型2a的丙型肝炎病毒的全长基因组RNA序列，至少一种选择标记基因和/或至少一种报告基因 和至少一个IRES序列或基因型2a的丙型肝炎病毒的全长基因组RNA被引入，并在培养基中产生病毒颗粒。 更进一步地，本发明涉及这样一种丙型肝炎疫苗和抗丙型肝炎病毒颗粒的抗体。
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2.发明授权NUCLEIC ACID CONSTRUCT CONTAINING FULL-LENGTH GENOME OF HUMAN HEPATITIS C VIRUS, RECOMBINANT FULL-LENGTH VIRUS GENOME REPLICATIVE CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO AND METHOD OF CONSTRUCTING HEPATITIS C VIRAL PARTICLES 有权与VOLLÄNGENGENOM人丙型肝炎病毒，重组病毒基因组全长滚动细胞透过您在施工丙型肝炎病毒颗粒传送核构建和方法的核构建
公开(公告)号：EP1721985B1
公开(公告)日：2010-06-30
申请号：EP05719575.2
申请日：2005-02-21
发明人： WAKITA, Takaji , KATO, Takanobu , DATE, Tomoko; , MIYAMOTO, Michiko; , TANABE, Jun-ichi , SONE, Saburo;
IPC分类号： C12N15/63 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/01 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/567 , C07K16/08 , A61K35/76 , A61P37/04
CPC分类号： C12N7/00 , A61K2039/525 , C07K16/109 , C12N15/86 , C12N2770/24221 , C12N2770/24243 , C12N2840/203 , G01N33/5767
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