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    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
    6.
    发明公开
    PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER 审中-公开

    公开(公告)号：EP3498284A1

    公开(公告)日：2019-06-19

    申请号：EP17839518.2

    申请日：2017-08-09

    申请人： Toray Industries, Inc.

    发明人： MIYANO, Atsuko ,  TAKAYAMA, Aiko ,  SUDO, Hiroko ,  ARAI, Taiga

    IPC分类号： A61K31/7105 ,  A61K31/711 ,  A61K48/00 ,  A61P35/00 ,  C12N15/113

    摘要： It is an object of the present invention to specify miRNA associated with the treatment and/or prevention of various cancer species, from among various miRNAs associated with cancer, and to provide a novel pharmaceutical composition for treating and/or preventing cancer which targets the specified miRNA. According to the present invention, provided are a pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, an antisense polynucleotide shown as hsa-miR4454, a combination drug comprising the aforementioned pharmaceutical composition and another antitumor agent, and a method for treating and/or preventing cancer, using the above-described pharmaceutical composition or combination drug.

    MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR INSPECTING SAME
    8.
    发明公开
    MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR INSPECTING SAME 审中-公开
    VERFAHREN ZUM NACHWEIS VON KOLOREKTALKARZINOM

    公开(公告)号：EP2752666A1

    公开(公告)日：2014-07-09

    申请号：EP12828352.0

    申请日：2012-08-28

    申请人： Toray Industries, Inc. ,  Kyoto University

    发明人： KOBAYASHI, Michimoto ,  TANAKA, Yoshinori ,  TAKAYAMA, Aiko ,  JUNG, Giman ,  SAKAI, Yoshiharu ,  OKABE, Hiroshi

    IPC分类号： G01N33/68 ,  C07K16/18 ,  C12Q1/02 ,  G01N33/574

    CPC分类号： G01N33/57496 ,  C07K16/18 ,  C07K16/3046 ,  G01N33/57419

    摘要： This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.

    摘要翻译： 本发明涉及一种用于检测或检测选自结肠直肠癌和食管癌的癌症的方法，其具有高检测灵敏度和准确性并且对受试者的侵袭性较小。 具体地说，本发明涉及一种检查癌症的方法，其特征在于，在体外测定来自受试者的体液样品中的COTL1蛋白质，根据测定的COTL1蛋白质量，评价受试者是否患有癌症。 它还涉及用于诊断选自结肠直肠癌和食管癌的癌症的试剂盒，其包含能够特异性结合蛋白质的抗体或其片段。

    IMMUNOLOGICAL cofilin-1 PROTEIN MEASUREMENT METHOD
    9.
    发明公开
    IMMUNOLOGICAL cofilin-1 PROTEIN MEASUREMENT METHOD 审中-公开
    免疫组织化学蛋白-1蛋白 - 信使

    公开(公告)号：EP2650307A1

    公开(公告)日：2013-10-16

    申请号：EP11846996.4

    申请日：2011-12-05

    申请人： Toray Industries, Inc. ,  Kyoto University

    发明人： KOBAYASHI, Michimoto ,  TANAKA, Yoshinori ,  TAKAYAMA, Aiko ,  KANAMORI, Satoko ,  JUNG, Giman ,  SAKAI, Yoshiharu ,  OKABE, Hiroshi

    IPC分类号： C07K16/18 ,  G01N33/574 ,  G01N33/577 ,  C12N15/09 ,  C12P21/08

    CPC分类号： C07K16/18 ,  C07K2317/34 ,  G01N33/57446 ,  G01N33/577

    摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

    摘要翻译： 本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定 片段。 使用2种或2种以上抗纤维蛋白1单克隆抗体或其片段特异性识别构成该蛋白1蛋白质的氨基酸序列中的不同肽区域的样品，对样品中的香草素1或其片段进行测定，对其进行免疫测定。