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1.发明公开Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester having an improved solubility 失效Verfahren zur Herstellung von alpha-L-Aspartyl-L-phenylalanin-methyl-ester mit verbesserterLöslichkeit。
公开(公告)号：EP0255092A2
公开(公告)日：1988-02-03
申请号：EP87110866.8
申请日：1987-07-27
Applicant: TOSOH CORPORATION
Inventor： Wakamatsu, Hidetoshi , Irino, Shigeaki , Harada, Tsuneo , Tokuda, Akira , Oyama, Kiyotaka
IPC: C07K5/06
CPC classification number: C07K5/0613
Abstract: A process for producing dry α-L-aspartyl-L-phenylalanine methyl ester having an improved solubility from wet crystals of α-L-aspartyl-L-phenylalanine methyl ester having a water content of at least 20% by weight, which comprises drying the wet crystals at a temperature of higher than 50°C to obtain moist crystals having a water content of less than 20 and more than l5% by weight, then drying the moist crystals at a temperature of not higher than 50°C to obtain semi-dry crystals having a water content of less than 5% by weight, and further drying the semi-dry crystals at a temperature of higher than 50°C to obtain dry crystals of α-L-aspartyl-L-phenylalanine methyl ester.
Abstract translation: 一种具有水含量为至少20重量％的α-L-天冬氨酰-L-苯丙氨酸甲酯的湿结晶具有改善的溶解度的干燥α-L-天冬氨酰-L-苯丙氨酸甲酯的方法，其包括干燥 在高于50℃的温度下的湿结晶，得到含水量小于20且大于15重量％的湿结晶，然后在不高于50℃的温度下干燥湿结晶，得到半 水分含量小于5重量％的水溶液，并在高于50℃的温度下干燥半干燥晶体，得到α-L-天冬氨酰基-L-苯丙氨酸甲酯的干结晶。
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2.发明授权
公开(公告)号：EP0399605B1
公开(公告)日：1996-02-14
申请号：EP90201273.1
申请日：1990-05-19
Applicant: STAMICARBON B.V. , TOSOH CORPORATION
Inventor： Irino, Shigeaki , Wakamatsu, Hidetoshi , Kunisawa, Yukio , Stoelwinder, Christiaan Johannes Cornelis , Toussaint, Antoon Gerard Theodoor
CPC classification number: C07K5/0613
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3.发明公开Process for producing stable alpha-L-aspartyl-L-phenylalanine methyl ester 失效Verfahren zur Herstellung von stabilemα-L-天冬氨酰-L-苯丙氨酸甲酯。
公开(公告)号：EP0256517A2
公开(公告)日：1988-02-24
申请号：EP87111701.6
申请日：1987-08-12
Applicant: TOSOH CORPORATION
Inventor： Wakamatsu, Hidetoshi , Irino, Shigeaki , Harada, Tsuneo , Tokuda, Akira , Oyama, Kiyotaka
IPC: C07K5/06
CPC classification number: C07K5/0613
Abstract: A process for producing stable α-L-aspartyl-L-phenylalanine methyl ester, which comprises heat-treating crystals of α-L-aspartyl-L-phenylalanine methyl ester having a water content of from 5 to l5% by weight based on wet crystals, at a temperature of higher than 50°C and lower than 80°C for at least 30 minutes.
Abstract translation: 一种制备稳定的α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法，其包括将基于湿的5〜15重量％的含水量的α-L-天冬氨酰基-L-苯丙氨酸甲酯的晶体进行热处理 晶体，在高于50℃且低于80℃的温度下至少30分钟。
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Patent Agency Ranking4.发明公开Ion-exchanger, process for production thereof and process for removal of multicharged anions employing the ion-exchanger 失效离子交换剂，处理其制备及其用于mehrwärtigen去除阴离子
公开(公告)号：EP0815939A2
公开(公告)日：1998-01-07
申请号：EP97111301.4
申请日：1997-07-04
Applicant: Tosoh Corporation
Inventor： Wakamatsu, Hidetoshi , Sakurai, Manabu , Murakami, Tsugio , Kumoi, Sadakatsu
Abstract: An ion-exchanger is provided which comprises zirconium hydroxide supported on active carbon. A process for producing the ion-exchanger, and a process for removing a multiply charged anion by using the ion-exchanger are also provided. The ion-exchanger of the present invention has high chemical resistance, high heat resistance, high mechanical strength, and excellent ion exchange characteristics.
Abstract translation: 本发明提供一种离子交换剂，它包括载于活性炭的氢氧化锆。 因此，提供一种用于制造该离子交换剂，以及用于通过使用离子交换剂除去多电荷阴离子的处理过程。 本发明的离子交换剂具有高的耐化学性，高耐热性，高机械强度和优异的离子交换特性。
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5.发明公开Ion-exchanger, process for production thereof and process for removal of multicharged anions employing the ion-exchanger 失效离子交换剂，处理其制备及其用于mehrwärtigen去除阴离子
公开(公告)号：EP0815939A3
公开(公告)日：1998-03-11
申请号：EP97111301.4
申请日：1997-07-04
Applicant: Tosoh Corporation
Inventor： Wakamatsu, Hidetoshi , Sakurai, Manabu , Murakami, Tsugio , Kumoi, Sadakatsu
Abstract: An ion-exchanger is provided which comprises zirconium hydroxide supported on active carbon. A process for producing the ion-exchanger, and a process for removing a multiply charged anion by using the ion-exchanger are also provided. The ion-exchanger of the present invention has high chemical resistance, high heat resistance, high mechanical strength, and excellent ion exchange characteristics.
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6.发明公开Process for producing alpha-l-aspartyl-l-phenylalanine methyl ester having an improved solubility 失效生产具有改进的溶解度的α-1-天冬氨酰基-1-苯丙氨酸甲酯的方法
公开(公告)号：EP0255092A3
公开(公告)日：1989-04-19
申请号：EP87110866.8
申请日：1987-07-27
Applicant: TOSOH CORPORATION
Inventor： Wakamatsu, Hidetoshi , Irino, Shigeaki , Harada, Tsuneo , Tokuda, Akira , Oyama, Kiyotaka
IPC: C07K5/06
CPC classification number: C07K5/0613
Abstract: A process for producing dry α-L-aspartyl-L-phenylalanine methyl ester having an improved solubility from wet crystals of α-L-aspartyl-L-phenylalanine methyl ester having a water content of at least 20% by weight, which comprises drying the wet crystals at a temperature of higher than 50°C to obtain moist crystals having a water content of less than 20 and more than l5% by weight, then drying the moist crystals at a temperature of not higher than 50°C to obtain semi-dry crystals having a water content of less than 5% by weight, and further drying the semi-dry crystals at a temperature of higher than 50°C to obtain dry crystals of α-L-aspartyl-L-phenylalanine methyl ester.
Abstract translation: 一种生产干燥的α-L-天冬氨酰-L-苯丙氨酸甲酯的方法，该干燥的α-L-天冬氨酰-L-苯丙氨酸甲酯具有至少20％（重量）的含水量的α-L-天冬氨酰-L-苯丙氨酸甲酯的湿结晶，其中包括干燥 在高于50℃的温度下湿结晶以获得含水量小于20和大于15重量％的湿结晶，然后在不高于50℃的温度下干燥湿结晶以获得半成品 干燥晶体的水含量小于5重量％，并在高于50℃的温度下进一步干燥半干燥晶体，得到α-L-天冬氨酰-L-苯丙氨酸甲酯的干燥晶体。
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7.发明授权
公开(公告)号：EP0815939B1
公开(公告)日：2003-02-26
申请号：EP97111301.4
申请日：1997-07-04
Applicant: Tosoh Corporation
Inventor： Wakamatsu, Hidetoshi , Sakurai, Manabu , Murakami, Tsugio , Kumoi, Sadakatsu
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8.发明公开Process for producing stable alpha-L-aspartyl-L-phenylalanine methyl ester 失效生产稳定型ALPHA-L-ASPARTYL-L-PHENYLALANINE METHYLESTER的方法
公开(公告)号：EP0256517A3
公开(公告)日：1989-04-26
申请号：EP87111701.6
申请日：1987-08-12
Applicant: TOSOH CORPORATION
Inventor： Wakamatsu, Hidetoshi , Irino, Shigeaki , Harada, Tsuneo , Tokuda, Akira , Oyama, Kiyotaka
IPC: C07K5/06
CPC classification number: C07K5/0613
Abstract: A process for producing stable α-L-aspartyl-L-phenylalanine methyl ester, which comprises heat-treating crystals of α-L-aspartyl-L-phenylalanine methyl ester having a water content of from 5 to l5% by weight based on wet crystals, at a temperature of higher than 50°C and lower than 80°C for at least 30 minutes.
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