公开(公告)号：EP2491020A1

公开(公告)日：2012-08-29

申请号：EP10825750.2

申请日：2010-10-22

申请人： Tranzyme Pharma, Inc. ,  Université de Sherbrooke

发明人： MARSAULT, Éric ,  LEOGANE, Olivier ,  MATHIEU, Axel ,  BEAUBIEN, Sylvie ,  LEDUC, Richard

IPC分类号： C07D225/00

CPC分类号： A61K31/395

摘要： The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes and methods of using the compounds. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the same. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.

公开(公告)号：EP2491004A2

公开(公告)日：2012-08-29

申请号：EP10825746.0

申请日：2010-10-22

申请人： Tranzyme Pharma, Inc.

发明人： MARSAULT, Éric ,  LEOGANE, Olivier ,  MATHIEU, Axel ,  BEAUBIEN, Sylvie

IPC分类号： C07C225/00

CPC分类号： A61K31/395

摘要： The present invention relates to novel macrocyclic compounds and salts thereof that bind to and/or are inhibitors of serine protease enzymes. The present invention also relates to intermediates of these compounds, pharmaceutical compositions containing these compounds and methods of using the compounds. These compounds are useful as therapeutics for treatment and prevention of a range of disease indications including hyperproliferative disorders, in particular those characterized by tumor metastasis, inflammatory disorders, skin and tissue disorders, cardiovascular disorders, respiratory disorders and viral infections.