公开(公告)号：EP2118080A1

公开(公告)日：2009-11-18

申请号：EP08799889.4

申请日：2008-02-08

申请人： Tranzyme Pharma, Inc.

发明人： HOVEYDA, Hamid ,  FRASER, Graeme ,  BEAUCHEMIN, Sophie ,  BRASSARD, Martin ,  DRUTZ, David ,  MARSAULT, Éric ,  OUELLET, Luc ,  PETERSON, Mark, L. ,  WANG, Zhigang ,  BENAKLI, Kamel

IPC分类号： C07D273/00 ,  C07K5/12 ,  A61K38/00 ,  A61P1/00

CPC分类号： A61K31/395 ,  C07C215/42 ,  C07C215/54 ,  C07C271/16 ,  C07C2601/14 ,  C07D273/00 ,  C07D413/06 ,  C07D498/04 ,  C07D498/16

摘要： The present invention relates to intermediates of conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the ghrelin (growth hormone secretagogue) receptor including GHS-R1a and subtypes, isoforms and/or variants thereof and the use of these interemdaites to prepare said macrocyclic compounds.