公开(公告)号：EP3319511A1

公开(公告)日：2018-05-16

申请号：EP16835748.1

申请日：2016-08-08

申请人： Trustees of Boston University ,  The General Hospital Corporation

发明人： EL-KHATIB, Firas ,  DAMIANO, Edward ,  RUSSELL, Steven J.

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/4839 ,  A61M5/1723 ,  A61M2005/14208

摘要： A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.

公开(公告)号：EP3957233A2

公开(公告)日：2022-02-23

申请号：EP21196917.5

申请日：2016-08-08

申请人： Trustees of Boston University ,  The General Hospital Corporation

发明人： EL-KHATIB, Firas ,  DAMIANO, Edward ,  RUSSELL, Steven J.

IPC分类号： A61B5/00

摘要： A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.

公开(公告)号：EP3957233A3

公开(公告)日：2022-05-11

申请号：EP21196917.5

申请日：2016-08-08

申请人： Trustees of Boston University ,  The General Hospital Corporation

发明人： EL-KHATIB, Firas ,  DAMIANO, Edward ,  RUSSELL, Steven J.

IPC分类号： A61B5/00

摘要： A glucose control system employs adaptation of a glucose target (set-point) control variable in controlling delivery of insulin to a subject to maintain euglycemia. The glucose target adapts based on trends in actual glucose level (e.g., measured blood glucose in the subject), and/or computed doses of a counter-regulatory agent such as glucagon. An adaptation region with upper and lower bounds for the glucose target may be imposed. Generally the disclosed techniques can provide for robust and safe glucose level control. Adaptation may be based on computed doses of a counter-regulatory agent whether or not such agent is actually delivered to the subject, and may be used for example to adjust operation in a bihormonal system during periods in which the counter-regulatory agent is not available for delivery.