公开(公告)号：EP4450624A1

公开(公告)日：2024-10-23

申请号：EP22906685.7

申请日：2022-12-16

申请人： Tuojie Biotech (Shanghai) Co., Ltd.

发明人： LI, Yunfei ,  DENG, Yongyan ,  HOU, Zhe ,  ZHANG, Jianyu ,  WANG, Yanhui ,  MAO, Song ,  HUANG, Jinyu ,  LIU, Nan ,  CAI, Guoqing ,  LV, Zhenzhen ,  HUANG, Yanfen ,  ZHOU, Yaqin ,  LUO, Min ,  ZHANG, Fang

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61K48/00 ,  A61P9/10

摘要： The present invention relates to LPA-targeting siRNA and a conjugate, and specifically relates to LPA-targeting siRNA, a siRNA conjugate, a composition, and a pharmaceutical use thereof. The present invention also relates to a pharmaceutical composition, a cell or a kit comprising the siRNA, and a method for the siRNA and the siRNA conjugate for treating and/or preventing related disorders suffered by a subject.

公开(公告)号：EP4365290A1

公开(公告)日：2024-05-08

申请号：EP22832207.9

申请日：2022-07-01

申请人： Tuojie Biotech (Shanghai) Co., Ltd.

发明人： HUANG, Jinyu ,  LUO, Min ,  YIN, Ke ,  HOU, Zhe ,  LI, Yunfei

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61K31/713 ,  A61P1/16

CPC分类号： C12N15/113 ,  A61P1/16 ,  A61K47/549 ,  C12N15/111 ,  C12N2310/1420130101 ,  C12N2310/35120130101 ,  C12N2320/3220130101

摘要： A nucleic acid ligand and a conjugate thereof, and a preparation method therefor and the use thereof. Specifically, provided is a ligand having the structure as represented by formula (I). The provided ligand achieves a good expression inhibition effect by means of the conjugation with a nucleic acid.

公开(公告)号：EP4328310A1

公开(公告)日：2024-02-28

申请号：EP22791121.1

申请日：2022-04-22

申请人： Tuojie Biotech (Shanghai) Co., Ltd.

发明人： HUANG, Jinyu ,  HUANG, Yanfen ,  LUO, Min ,  ZHANG, Fang

IPC分类号： C12N15/113 ,  A61K31/713

摘要： An siRNA targeting 17β-hydroxysteroid dehydrogenase type 13 and a siRNA conjugate. Also disclosed are a pharmaceutical composition, cell or kit containing the siRNA, and a method for using the siRNA for the treatment and/or prevention of subjects suffering from HSD17B13-related disorders (such as chronic fibroinflammatory liver disease).

公开(公告)号：EP4194553A1

公开(公告)日：2023-06-14

申请号：EP21852482.5

申请日：2021-08-04

申请人： Tuojie Biotech (Shanghai) Co., Ltd.

发明人： HUANG, Jinyu ,  LUO, Min ,  YIN, Ke

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K48/00

摘要： Disclosed is a modified siRNA with a reduced off-target activity. The siRNA comprises a sense strand and an antisense strand, wherein the antisense strand contains a chemical modification as represented by formula (I) or a tautomeric modification thereof in at least one nucleotide position from position 2 to position 8 of 5' region thereof. A conjugate, a pharmaceutical composition, a cell or a kit containing the siRNA, and the medical use of the siRNA, the conjugate and/or the pharmaceutical composition thereof are also disclosed. Further disclosed are compounds as represented by formula (II) and formula (III) or tautomers thereof, and preparation methods therefor.

公开(公告)号：EP4435104A1

公开(公告)日：2024-09-25

申请号：EP22894956.6

申请日：2022-11-18

申请人： Tuojie Biotech (Shanghai) Co., Ltd.

发明人： LIN, Xiaoyan ,  LI, Yunfei ,  ZHANG, Zhen ,  DONG, Yuqiong ,  HOU, Zhe ,  ZHANG, Jianyu ,  GENG, Jun ,  MAO, Song ,  HUANG, Longfei ,  ZHOU, Yaqin ,  LV, Zhenzhen ,  HUANG, Yanfen ,  HUANG, Jinyu

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P9/12 ,  A61P9/10 ,  A61P13/12

CPC分类号： C12N15/113 ,  A61P9/12 ,  A61P9/10 ,  A61K31/713 ,  A61P13/12

摘要： An siRNA targeting angiotensinogen (AGT) and a pharmaceutical use of the siRNA. Specifically, the present invention relates to the siRNA targeting an AGT gene, an siRNA conjugate or a dsRNA, a composition, and a pharmaceutical use of the siRNA. The present invention also relates to a pharmaceutical composition, a cell or a kit comprising the siRNA, and a method for the siRNA to treat and/or prevent AGT-related disorders (such as hypertension).