公开(公告)号：EP0815128A2

公开(公告)日：1998-01-07

申请号：EP96904088.0

申请日：1996-02-27

申请人： UNILEVER PLC ,  UNILEVER N.V.

发明人： BHAKOO, Manmohan ,  PATEL, Shail ,  STOTT, Peter, Ian

IPC分类号： A01N37 ,  C07K7 ,  C07K14 ,  A61K38

CPC分类号： C07K7/08 ,  A01N37/46 ,  A61K38/00 ,  C07K14/46 ,  Y02A50/473

摘要： The invention relates to amphiphilic peptides and analogs thereof. The specification defines the molecules in three ways and discloses that antimicrobial peptides which comprise a sequence selected from the group comprising: +-++--++--+--++, +-++--++---+-+++, ++-+++-++-+++--, ++-+++-++-++++-++-, ++-+++-++--++--++-, --++--++-++--++-++, ++++-+++--+--++, ++-+++++++-++-++--, wherein + indicates a hydrophobic amino acid residue and - indicates a hydrophilic amino acid residue have improved antimicrobial properties. Specific sequences of active peptides are given. The specification also discloses two general equations which define the rule by whicc peptides falling within the scope of the invention are identified.

公开(公告)号：EP1351658B1

公开(公告)日：2005-03-02

申请号：EP01990542.1

申请日：2001-12-07

申请人： UNILEVER N.V. ,  UNILEVER PLC

发明人： BHAKOO, Manmohan ,  JOINER, Andrew ,  STEELE, Karen,Anne ,  TAYLOR, David ,  THOMPSON, Katherine, Mary ,  THORNTHWAITE, David, Wiliam

IPC分类号： A61K7/16 ,  A61K7/20 ,  A61K7/22

CPC分类号： C11D3/48 ,  A61K8/02 ,  A61K8/046 ,  A61K8/19 ,  A61K8/22 ,  A61K8/38 ,  A61K8/42 ,  A61K8/44 ,  A61K8/4926 ,  A61K8/63 ,  A61K2800/874 ,  A61Q11/00 ,  A61Q15/00 ,  C11D3/28 ,  C11D3/33 ,  C11D3/3942 ,  C11D3/3947

摘要： An oral composition comprising picolinic acid and a peroxyl species or equivalent source thereof, characterised in that the molar ratio of picolinic acid to peroxyl species or equivalent source thereof is from 1:30 to 100:1.

公开(公告)号：EP0722327A1

公开(公告)日：1996-07-24

申请号：EP94928834.0

申请日：1994-09-28

申请人： UNILEVER PLC ,  UNILEVER N.V.

发明人： BHAKOO, Manmohan

IPC分类号： A61K9 ,  A01N37 ,  A61K8 ,  A61K31 ,  A61K38 ,  A61P31 ,  A61Q5 ,  A61Q11 ,  A61Q19 ,  C08G69

CPC分类号： A61Q11/00 ,  A61K8/88 ,  A61K31/785 ,  C08G69/10

摘要： The present invention relates to antibacterial compositions comprising particular compounds, to the use of said compounds as antibacterial agents, to the preparation of therapeutic or medicinal compositions comprising said compounds and to a method of disinfecting matter including the step of treating matter with said compounds. The compounds are identified as peptides having a molecular weight of at least 5kD, comprising at least 15 % by number of residues of arginine, lysine, ornithine or a mixture thereof and at least 15 % by number of residues of arginine, lysine, ornithine, phenylalanine, tyrosine, tryptophan or a mixture thereof. Although the invention is described with reference to use in the fields of food and oral hygiene, the invention has particular utility in the field of household and/or industrial hygiene.

公开(公告)号：EP1351658A1

公开(公告)日：2003-10-15

申请号：EP01990542.1

申请日：2001-12-07

申请人： UNILEVER N.V. ,  UNILEVER PLC

发明人： BHAKOO, Manmohan ,  JOINER, Andrew ,  STEELE, Karen,Anne ,  TAYLOR, David ,  THOMPSON, Katherine, Mary ,  THORNTHWAITE, David, Wiliam

IPC分类号： A61K7/16 ,  A61K7/20 ,  A61K7/22

CPC分类号： C11D3/48 ,  A61K8/02 ,  A61K8/046 ,  A61K8/19 ,  A61K8/22 ,  A61K8/38 ,  A61K8/42 ,  A61K8/44 ,  A61K8/4926 ,  A61K8/63 ,  A61K2800/874 ,  A61Q11/00 ,  A61Q15/00 ,  C11D3/28 ,  C11D3/33 ,  C11D3/3942 ,  C11D3/3947

摘要： An oral composition comprising picolinic acid and a peroxyl species or equivalent source thereof, characterised in that the molar ratio of picolinic acid to peroxyl species or equivalent source thereof is from 1:30 to 100:1.

摘要翻译： 包含吡啶甲酸和过氧化氢物质或其等效来源的口服组合物，其特征在于，吡啶甲酸与过氧化氢物质或其等同来源的摩尔比为1:30至100:1。

公开(公告)号：EP0722327B1

公开(公告)日：2000-11-22

申请号：EP94928834.4

申请日：1994-09-28

申请人： UNILEVER PLC ,  UNILEVER N.V.

发明人： BHAKOO, Manmohan

IPC分类号： A61K31/785 ,  C08G69/10

CPC分类号： A61Q11/00 ,  A61K8/88 ,  A61K31/785 ,  C08G69/10

摘要： The present invention relates to antibacterial compositions comprising particular compounds, to the use of said compounds as antibacterial agents, to the preparation of therapeutic or medicinal compositions comprising said compounds and to a method of disinfecting matter including the step of treating matter with said compounds. The compounds are identified as peptides having a molecular weight of at least 5kD, comprising at least 15 % by number of residues of arginine, lysine, ornithine or a mixture thereof and at least 15 % by number of residues of arginine, lysine, ornithine, phenylalanine, tyrosine, tryptophan or a mixture thereof. Although the invention is described with reference to use in the fields of food and oral hygiene, the invention has particular utility in the field of household and/or industrial hygiene.