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1.发明公开COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF 审中-公开连接，骨TARGET收缩单位结合肽和方法进行生产及其用途
公开(公告)号：EP2488208A4
公开(公告)日：2015-07-01
申请号：EP10823111
申请日：2010-10-12
申请人： UNIV ALBERTA
CPC分类号： A61K47/48 , A61K38/23 , A61K47/50 , A61K47/548
摘要： Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic applications including treating or preventing conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Osteoarthritis, osteopenia, and hypercalcemia. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and methods of preventing bone fractures.
摘要翻译： 描述中是具有肽序列的组合物确实包括至少一个骨靶向部分，worin骨靶向部分是由左结合到肽序列，worin肽序列是降钙素和worin所述组合物是中性或药学上可接受的盐 或酯。 在一个方面，降钙素抑制或减缓破骨细胞介导的骨吸收损失。 中所述的化合物可以以多种治疗应用，包括治疗或预防与骨损失，这包括相关联的条件下使用，但不限于，骨质疏松症，佩吉特氏病，溶骨性肿瘤，类风湿关节炎，银屑病关节炎，强直性脊柱炎，骨关节炎 ，骨质疏松和高钙血症。 如此描述的是使合成的组合物并预防或治疗与骨损失和预防骨折的方法相关条件的方法。
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