公开(公告)号：EP3285751A1

公开(公告)日：2018-02-28

申请号：EP16783970

申请日：2016-04-22

申请人： UNIV BRIGHAM YOUNG

发明人： SAVAGE PAUL B ,  CHITRE SAURABH SHASHIKANT ,  VARIA KUNAL ARVIND ,  REECE HAYLEY ANN ,  JACKS THOMAS ELLIOT ,  MILLER ROSS ALLEN ,  RANDALL JARED LYNN

IPC分类号： A61K31/10 ,  A61K31/56 ,  A61P31/02

CPC分类号： C07J41/0088 ,  C07B2200/13 ,  C07C309/29 ,  C07C309/35 ,  C07J41/0061

摘要： Disclosed herein are acid addition salts of cationic steroidal antimicrobials ("CSAs" or "ceragenins") and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Embodiments include formulations and methods of administering acid addition salts of CSAs.

公开(公告)号：EP3285875A1

公开(公告)日：2018-02-28

申请号：EP16783976

申请日：2016-04-22

申请人： UNIV BRIGHAM YOUNG

发明人： SAVAGE PAUL B ,  JACKS THOMAS ELLIOT ,  MILLER ROSS ALLEN ,  THOMPSON ANDREW STEVEN ,  RANDALL JARED LYNN

IPC分类号： A61P31/22 ,  A61K39/42 ,  C12Q1/70

CPC分类号： C07J41/0088 ,  C07J9/005 ,  C07J41/0055 ,  C07J41/0061

摘要： Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.