专利检索 ap:("UNIV CARMEL HAIFA ECONOMIC COR" OR "UNIV ROCKEFELLER") AND inv:"LARISCH SARIT" 第 1 页

1.

发明公开
Sept4/ARTS AS A TUMOR SUPPRESSOR IN THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF HEPATIC DISORDERS 审中-公开
标题翻译： SEPT4 / ARTS作为肿瘤抑制诊断，预后和治疗肝脏疾病的

公开(公告)号：EP2983693A4

公开(公告)日：2016-10-26

申请号：EP14782569

申请日：2014-04-07

申请人： UNIV CARMEL HAIFA ECONOMIC COR , UNIV ROCKEFELLER

发明人： LARISCH SARIT , STELLER HERMANN

IPC分类号： A61K38/17 , A61P1/16 , A61P35/00 , C12Q1/68 , G01N33/574

CPC分类号： C12Q1/6886 , A61K31/185 , A61K31/53 , A61K38/17 , C12Q2600/118 , C12Q2600/154 , G01N33/57438 , G01N33/576 , G01N2800/08 , G01N2800/085 , G01N2800/52 , G01N2800/54

摘要： The invention relates to methods for the diagnosis and prognosis of hepatic disorder and associated pathologies as well as of a solid proliferative disorder in a mammalian subject. More specifically, the methods of the invention are based on determining the expression, methylation of ARTS as well as histone trimethylation. The invention further provides therapeutic methods for treating said disorders.

2.

发明公开
ANTAGONISTS OF Bcl-2 AND USES THEREOF IN INDUCTION OF APOPTOSIS 审中-公开
标题翻译： BCL-2拮抗剂及其用途凋亡诱导

公开(公告)号：EP2814839A4

公开(公告)日：2015-09-23

申请号：EP13749592

申请日：2013-02-14

申请人： UNIV CARMEL HAIFA ECONOMIC COR

发明人： LARISCH SARIT

IPC分类号： C07K14/47 , A61K38/17

CPC分类号： C07K14/4747 , A61K38/00 , G01N33/68 , G01N33/6893 , G01N2333/4704 , G01N2510/00 , G01N2800/52

摘要： The present invention provides an antagonist of a Bcl-2 pro survival protein containing a BH3-like domain. The antagonist of the invention comprises ARTS and any fragment or peptide that comprises a BH3-like domain. The invention further provides compositions, combined compositions and kits as well as methods for treating Bcl-2 over-expressing disorders.