公开(公告)号：EP2600892A4

公开(公告)日：2014-03-05

申请号：EP11815191

申请日：2011-08-02

申请人： UNIV GEORGIA

发明人： GARCIA MARICARMEN ,  MUNDT ALICE ,  MUNDT EGBERT

IPC分类号： A61K39/245 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12 ,  A61K39/265 ,  A61P31/20 ,  C07K14/005 ,  C12N7/00 ,  C12N15/34 ,  C12N15/86

CPC分类号： A61K39/12 ,  A61K35/76 ,  A61K39/265 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16021 ,  C12N2710/16022 ,  C12N2710/16034 ,  C12N2710/16043 ,  C12N2710/16062 ,  C12N2760/18134

摘要： Provided herein are modified infectious largotracheitis viruses (ILTVs) and methods of using the same. For example, provided are attenuated ILTVs. The attenuated ILTVs can be used to illicit immune responses in avian species. Optionally, the attenuated ILTVs can be used to vaccinate an avian subject or a population of avian subjects. Optionally, an attenuated ILTV is administered in ovo to an avian egg. One or more such in ovo administration can be used to increase the immunity of an avian herd.