专利检索 ap:("UNIV NEW YORK STATE RES FOUND") AND inv:"COBURN ROBERT A" 第 1 页

1.

发明公开
NAPHTHYLSALICYLANILIDES AS ANTIMICROBIAL AND ANTIINFLAMMATORY AGENTS 有权
标题翻译： Naphthylsalicylanilides抗菌和消炎剂

公开(公告)号：EP1328507A4

公开(公告)日：2005-07-27

申请号：EP01979927

申请日：2001-10-02

申请人： UNIV NEW YORK STATE RES FOUND

发明人： COBURN ROBERT A , EVANS RICHARD T , GENCO ROBERT J

IPC分类号： A61P29/00 , A61K31/167 , A61P31/04 , C07C235/84 , C07C255/60 , C07C233/65 , A61K31/165 , A61K31/265 , C07C255/50

CPC分类号： C07C255/60 , C07C235/84

摘要： The present invention discloses novel naphthylsalicylanilides of the general formula (I) wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more -H with -OH, alkyl O-alkyl, branched alkyl, or cycloalkyl, containing 1-6 carbon atoms or combinations thereof. Y is a substituted or unsubstituted phenyl ring or substituted or unsubstituted naphthyl ring. The substitution for Y includes replacement of one or more -H atoms with Cn, CF3, NO2, methoxy, benzoyl, phenoxy, phenoxymethyl or combinations thereof. These compounds are useful as antibacterial against gram negative and gram positive bacteria and as antiinflammatory agents.