公开(公告)号：EP2836505A4

公开(公告)日：2015-12-02

申请号：EP13775839

申请日：2013-04-10

申请人： UNIV PENNSYLVANIA

发明人： WEINER DAVID B ,  CHOO DANIEL ,  MUTHUMANI KARUPPIAH ,  OBENG-ADJEI NYAMEKE ,  SCOTT VERONICA

IPC分类号： C07K14/135 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/70 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.