公开(公告)号：EP0821592A4

公开(公告)日：2000-03-01

申请号：EP96912950

申请日：1996-04-19

申请人： UNIV PENNSYLVANIA ,  UNIV NEW YORK

发明人： LAVKER ROBERT M ,  SUN TUNG-TIEN ,  YU DA-WEN

IPC分类号： A61K38/22 ,  A61K45/00 ,  A61P43/00 ,  C12N5/071 ,  A61K38/48 ,  A61K7/06 ,  A61K35/36 ,  A61K38/19 ,  A61K38/57 ,  C12N5/00

CPC分类号： C12N5/0627 ,  C12N2501/998

摘要： A method of modulating hair growth by contacting selected cells with a selected growth-modulating molecule is provided. A method for hair reconstitution or transplantation by expanding selected cells in vitro and combining them with other cells that regulate hair growth are also provided. Compositions containing a growth-modulating molecule which is synthesized by follicular cells and which undergoes hair-cycle-dependent concentration changes in hair follicles are also provided.

摘要翻译： 提供了通过使所选择的细胞与选择的生长调节分子接触来调节毛发生长的方法。 还提供了通过在体外扩展选定细胞并将其与调节毛发生长的其它细胞组合的毛发重建或移植的方法。 还提供了含有通过滤泡细胞合成并且在毛囊中经历毛发周期依赖性浓度变化的生长调节分子的组合物。