公开(公告)号：EP0896655A4

公开(公告)日：2000-07-12

申请号：EP97917681

申请日：1997-03-27

申请人： UNIV PRINCETON

发明人： CATES GORDON D JR ,  DRIEHUYS BASTIAN ,  HAPPER WILLIAM ,  MIRON ELI ,  SAAM BRIAN ,  WALTER DANIEL ,  MIDDLETON HUNTER

IPC分类号： F25J1/00 ,  A61B5/055 ,  A61K49/18 ,  G01R33/28

CPC分类号： G01R33/282 ,  A61K49/1815 ,  Y10S62/919 ,  Y10S62/925

摘要： A method and apparatus for hyperpolarization of flowing noble gases is disclosed. The apparatus is capable of hyperpolarizing noble gases in a continuous flow arrangement. Noble gases such as xenon-129 and helium-3 can be hyperpolarized using the disclosed method and apparatus. Preferably, the noble gas is hyperpolarized via spin exchange between atoms of the noble gas and an alkali metal such as rubidium. Also, a method and apparatus for accumulation (17) and/or storage of hyperpolarized noble gases in a continuous flow arrangement is provided. The method and apparatus enable large scale production, storage, and usage of hyperpolarized noble gases for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.

公开(公告)号：EP0890066A4

公开(公告)日：2000-01-19

申请号：EP97917656

申请日：1997-03-27

申请人： UNIV PRINCETON

发明人： CATES GORDON D JR ,  DRIEHUYS BASTIAAN ,  HAPPER WILLIAM ,  MIRON ELI ,  SAAM BRIAN ,  WALTER DANIEL

IPC分类号： A61B5/055 ,  A61K49/18 ,  C01B23/00 ,  F25J1/00 ,  F25J3/06 ,  G01R33/28 ,  H05H3/02 ,  A61K49/00

CPC分类号： G01R33/282 ,  A61K49/1815 ,  C01B23/0036 ,  C01B2210/0037 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2215/36 ,  F25J2270/60 ,  F25J2270/904 ,  F25J2290/62 ,  H05H3/02 ,  Y10S62/919 ,  Y10S62/925

摘要： A method and apparatus for accumulation of hyperpolarized 129X e is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production, storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subjects through magnetic resonance imaging (MRI) techniques.