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    BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS
    1.
    发明公开
    BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS 有权
    FLUORESZENZSONDEN MIT BODIPY-STRUKTURFÜRVERSCHIEDENE BIOLOGISCHE ANWENDUNGEN

    公开(公告)号：EP2794620A4

    公开(公告)日：2015-09-02

    申请号：EP12859000

    申请日：2012-12-20

    申请人： UNIV SINGAPORE ,  AGENCY SCIENCE TECH & RES

    发明人： CHANG YOUNG-TAE ,  LEE SUNG CHAN ,  KANG NAM-YOUNG ,  YUN SEONG WOOK ,  LEONG CHERYL KIT MUN ,  HA HYUNG HO

    IPC分类号： C07F5/02 ,  G01N33/533

    CPC分类号： G01N33/5306 ,  A61K49/0021 ,  A61K49/006 ,  C07F5/02 ,  C07F5/022 ,  G01N33/56966 ,  G01N33/582 ,  G01N2458/00

    摘要： The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of beta cells, pancreatic islets and microglia cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can also differentiate healthy pancreatic islet cells from diabetic pancreatic islet cells.

    摘要翻译： 本发明涉及由结构式（I）表示的对神经干细胞特异性的荧光化合物：（I）或其药学上可接受的盐。 结构式（I）的变量在本文中定义。 还描述了用于检测β细胞，胰岛和小神经胶质细胞的方法，包括使用结构式（I）的化合物或其药学上可接受的盐。 结构式（I）的化合物还可以将健康胰岛细胞与糖尿病胰岛细胞分化。