公开(公告)号：EP2865384A4

公开(公告)日：2016-01-20

申请号：EP13807573

申请日：2013-06-21

申请人： UNIV TOKYO

发明人： HAMAKUBO TAKAO ,  TSUMOTO KOUHEI ,  DAIGO KENJI ,  INOUE KENJI ,  YAMAGUCHI NAOTAKA ,  MIZUUCHI MOTOAKI ,  FUJII HIROYA

IPC分类号： A61K38/00 ,  A61P29/00 ,  C07K14/435 ,  C07K14/47 ,  C12N15/09 ,  C12P21/02 ,  G01N33/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  G01N33/6875

摘要： The present invention provides a therapeutic or prophylactic agent for systemic inflammatory response syndrome (SIRS), which contains a polypeptide comprising an amino acid sequence the same or substantially the same as the amino acid sequence of the N-terminal domain of pentraxin 3 capable of binding to histone to form a polypeptide aggregate, or a pharmacologically acceptable salt thereof. The present invention also provides a reagent for quantification and a quantification method of histone, which utilize the polypeptide or a pharmacologically acceptable salt thereof. Furthermore, the present invention provides a polypeptide aggregate containing the polypeptide or a pharmacologically acceptable salt thereof and histone and a production method thereof.