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1.FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY 审中-公开
标题翻译: KONDENSIERTES PYRAZOLDERIVAT MIT AUTOTAXIN-HEMMENDER WIRKUNG公开(公告)号:EP3112369A4
公开(公告)日:2017-09-20
申请号:EP15754487
申请日:2015-02-26
申请人: UNIV TOKYO , UNIV TOHOKU , SHIONOGI & CO
发明人: NAGANO TETSUO , OKABE TAKAYOSHI , KOJIMA HIROTATSU , KAWAGUCHI MITSUYASU , NUREKI OSAMU , ISHITANI RYUICHIRO , NISHIMASU HIROSHI , AOKI JUNKEN , FUJIKOSHI CHIAKI , KATOU MANABU , ODAN MASAHIDE , TANAKA NOBUYUKI , TATENO YUSUKE , YAMANE JUNJI
IPC分类号: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61P1/16 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/04
CPC分类号: C07D487/04 , C07D487/18 , C07D491/147 , C07D519/00
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2.SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ß-SECRETASE-INHIBITING ACTIVITY 审中-公开
标题翻译: 含S B-分泌锁定效果的杂环衍生物公开(公告)号:EP2305672A4
公开(公告)日:2012-05-16
申请号:EP09762528
申请日:2009-06-11
申请人: SHIONOGI & CO
发明人: HORI AKIHIRO , YONEZAWA SHUJI , FUJIKOSHI CHIAKI , MATSUMOTO SAE , KOORIYAMA YUUJI , UENO TATSUHIKO , KATO TERUKAZU
IPC分类号: C07D417/12 , A61K31/4439 , A61K31/497 , A61K31/541 , A61P25/28 , A61P43/00 , C07D417/10 , C07D417/14
CPC分类号: C07D417/12 , A61K9/0019 , A61K9/1623 , A61K9/2018 , C07D279/06 , C07D417/10 , C07D417/14 , C07D487/04
摘要: The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid ² protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R 1 is optionally substituted lower alkyl or the like, R 2a and R 2b are each independently hydrogen, optionally substituted lower alkyl or the like, R 3a and R 3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
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3.AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUPS 有权
标题翻译: 与环基团取代AMINODIHYDROTHIAZIN衍生物公开(公告)号:EP2147914A4
公开(公告)日:2011-08-17
申请号:EP08751985
申请日:2008-04-23
申请人: SHIONOGI & CO
发明人: TAMURA YUUSUKE , SUZUKI SHINJI , TADA YUKIO , YONEZAWA SHUJI , FUJIKOSHI CHIAKI , MATSUMOTO SAE , KOORIYAMA YUUJI , UENO TATSUHIKO
IPC分类号: C07D279/06 , A61K31/497 , A61K31/54 , A61K31/541 , A61P25/28 , A61P43/00 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号: C07C215/20 , A61K9/0019 , A61K9/1623 , A61K9/2018 , C07D279/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D513/04
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