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    Immunosuppressive cyclolignan derivatives
    2.
    发明公开
    Immunosuppressive cyclolignan derivatives 失效
    免疫抑制剂Cyclolignanderivate

    公开(公告)号：EP0711765A1

    公开(公告)日：1996-05-15

    申请号：EP95308102.3

    申请日：1995-11-13

    申请人： UNIVERSIDAD DE SALAMANCA

    发明人： Gordaliza, Marina ,  Castro, Maria Angeles ,  San Feliciano, Arturo ,  del Corral, Jose Maria Miguel ,  Lopez, Maria Luisa ,  Faircloth, Glynn T. Pharma Mar S.A.

    IPC分类号： C07D307/92 ,  C07D493/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/365 ,  A61K31/415 ,  A61K31/42

    CPC分类号： C07D307/92 ,  C07D209/60 ,  C07D261/20 ,  C07D491/04 ,  C07D493/04

    摘要： Immunosuppressive cyclolignan derivatives are provided of formula (I) or (II):

    or

    in which R¹ is hydrogen, hydroxy, alkoxy; R and R³ are hydrogen, alkyl, acyl, or together R and R³ form a group -CHR⁴-; R⁴ is hydrogen, alkyl, alkenyl, hydroxyalkyl, (poly)haloalkyl, aryl, acyloxyalkyl, alkoxy, carboxyalkyl, alkoxycarbonyl, carbamoyl; R⁵ when present is hydrogen, alkyl, alkenyl, aryl, (poly)haloalkyl, acyl, carbamoyl, or thiocarbamoyl; R⁶ is alkyl, hydroxyalkyl, haloalkyl, acyl, acyloxyalkyl, carboxy or alkoxycarbonyl; Ar is 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; and X is nitrogen or oxygen.

    摘要翻译： 免疫抑制性环链烷醇衍生物由式（I）或（II）提供：其中R 1为氢，羟基，烷氧基; R 2和R 3是氢，烷基，酰基或一起R 2和R 3形成-CHR 4 - 基团。 R 4是氢，烷基，烯基，羟基烷基，（多）卤代烷基，芳基，酰氧基烷基，烷氧基，羧基烷基，烷氧基羰基，氨基甲酰基; R 5为氢，烷基，烯基，芳基，（多）卤代烷基，酰基，氨基甲酰基或硫代氨基甲酰基; R 6是烷基，羟基烷基，卤代烷基，酰基，酰氧基烷基，羧基或烷氧基羰基; Ar为3,4,5-三烷氧基苯基或4-羟基-3,5-二烷氧基苯基; X是氮或氧。

    Antineoplastic cyclolignan derivatives
    4.
    发明公开
    Antineoplastic cyclolignan derivatives 失效
    Antineoplastische Cycllignan-Derivate

    公开(公告)号：EP0711767A1

    公开(公告)日：1996-05-15

    申请号：EP95308101.5

    申请日：1995-11-13

    申请人： UNIVERSIDAD DE SALAMANCA

    发明人： Gordaliza, Marina ,  Castro, Maria Angeles ,  San Feliciano, Arturo ,  del Corral, Jose Maria Miguel ,  Lopez, Maria Luisa ,  Gravalos, Dolores G. c/o Pharma Mar S.A.

    IPC分类号： C07D317/70 ,  A61K31/335

    CPC分类号： C07D317/70

    摘要： Antineoplastic cyclolignan derivatives are of formula (I):

    in which
    Ar is a 3,4,5-trialkoxyphenyl or 4-hydroxy-3,5-dialkoxyphenyl; X is an oxygen, sulphur or nitrogen atom, a methine group =CH- or an alkylmethine group =C(alkyl)-; Y is a hydrogen atom or an alkyl, alkenyl, (poly)haloalkyl, aryl, hydroxy, alkoxy, amino, monoalkylamino, dialkylamino, (poly)haloalkylamino, arylamino, acyl or acetamido group, or the group Y is absent; Z is an alkyl, hydroxyalkyl, acyl, carboxy, alkoxycarbonyl or aryloxycarbonyl group; and the dotted lines indicate one double bond located at position Δ⁷⁻⁸ or Δ 8-8' .

    摘要翻译： 抗肿瘤环链烷酰胺衍生物具有式（I）：其中Ar是3,4,5-三烷氧基苯基或4-羟基-3,5-二烷氧基苯基的 X是氧，硫或氮原子，次甲基= CH-或烷基甲基= C（烷基） - ; Y是氢原子或烷基，烯基，（多）卤代烷基，芳基，羟基，烷氧基，氨基，单烷基氨基，二烷基氨基，（多）卤代烷基氨基，芳基氨基，酰基或乙酰氨基，或Y不存在; Z是烷基，羟基烷基，酰基，羧基，烷氧基羰基或芳氧基羰基; 并且虚线表示位于DELTA <7> <8>或DELTA <8-8'>的一个双键。