公开(公告)号：EP1778192A2

公开(公告)日：2007-05-02

申请号：EP05760593.3

申请日：2005-06-20

申请人： UNIVERSITA'DEGLI STUDI DI MILANO ,  Universita' Degli Studi Di Pavia

发明人： VIGO, Daniele ,  RUSSO, Vincenzo ,  FAUSTINI, Massimo ,  PACE, Mario, Francesco ,  MUNARI, Eleonora ,  TORRE, Maria, Luisa ,  CONTE, Ubaldo

IPC分类号： A61K9/16

CPC分类号： A61K9/1652 ,  A61K9/1623 ,  A61K9/1635 ,  A61K9/1694

摘要： The present invention relates to microparticulate systems consisting of a gastroresistant, biocompatible and biodegradable polymer matrix, comprising a gastroresistant and enterosoluble polymer, a cryoprotector or lyoprotector, a divalent or trivalent metal salt of i biocompatible and biodegradable polymer having acid groups, and biologically active substances. Such gastroresistant microparticulate systems are used for the administration, preferably oral, of biologically active substances to animal species. The special composition of such microparticulate systems allows the protection of said biologically active substances from degradation by proteases and gastric acid, allowing their release into the intestine, where they may perform their activities.

公开(公告)号：EP1962809A2

公开(公告)日：2008-09-03

申请号：EP06842805.1

申请日：2006-12-22

申请人： Universita' degli Studi di Milano ,  Universita' Degli Studi Di Pavia ,  Universita' Degli Studi di Salerno

发明人： VIGO, Daniele ,  FAUSTINI, Massimo ,  SCOCCA, Sarah ,  MUNARI, Eleonora ,  TORRE, Maria Luisa ,  CONTE, Ubaldo ,  DE SIMONE, Francesco ,  AQUINO, Rita Patrizia ,  LAURO, Maria Rosaria

IPC分类号： A61K9/16

CPC分类号： A61K9/1635 ,  A23K10/18 ,  A23K10/37 ,  A23K20/147 ,  A23K20/163 ,  A23K20/174 ,  A23K20/30 ,  A23K50/00 ,  A61K9/1617 ,  A61K9/1652 ,  Y02P60/877

摘要： The present invention relates to gastroresistant and enterosoluble microparticulate systems for the encapsulation of biologically active substances selected from: flavonoids, vitamins, antioxidants, immunostimulants, starchy and non-starchy polysaccharides, probiotics, prebiotics, intestinal trophism regulators, oligoelements, enzymes and bioactive peptides. Such microparticulate systems allow the administration of the aforementioned nutraceutic substances to animals such as porcines, bovines, caprines, ovines, equids, canids, felines, camelids, lagomorphs, rodents, fowl, and other mammals, including humans, fish and crustaceans, increasing the bioavailability.

公开(公告)号：EP1868588A2

公开(公告)日：2007-12-26

申请号：EP06727411.8

申请日：2006-04-03

申请人： UNIVERSITA' DEGLI STUDI DI MILANO ,  Universita' Degli Studi Di Pavia

发明人： VIGO, Daniele ,  TORRE, Maria, Luisa ,  FAUSTINI, Massimo ,  MUNARI, Eleonora ,  RUSSO, Vincenzo ,  CONTE, Ubaldo

IPC分类号： A61K9/50 ,  A61K35/52 ,  A61D19/02

CPC分类号： A61K35/52 ,  A61D19/022 ,  A61K9/501 ,  A61K9/5036 ,  A61K9/5089

摘要： Capsules or microcapsules comprising: a) a nucleus containing seminal material or the spermatozoa of animal species chosen from the group consisting of equids, buffalo, ovicaprids, canids, felids, lagomorphs, laboratory animal species chosen from mice and rats, and possibly man, b) a membrane of a bivalent or trivalent metal alginate.