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公开(公告)号：EP1714969A3
公开(公告)日：2010-03-03
申请号：EP06115792.1
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
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公开(公告)号：EP1746159A3
公开(公告)日：2009-11-25
申请号：EP06115801.0
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula:
5'N 1 X 1 X 2 CGTTN 2 3 '
wherein the immunostimulatory oligonucleotide includes a modified backbone, at least one nucleotide separates consecutive CpGs, X 1 X 2 is GpT or ApT, N 1 is any nucleotide that includes a 5' TC or TG, N 1 + N 2 is from 0-26 bases, and the immunostimulatory oligonucleotide is from 8-30 bases in length and begins with TC or TG at the 5' end, with the proviso that neither N 1 nor N 2 contains a CCGG quadmer or more than one CCG or CGG trimer.-
公开(公告)号：EP1714969A2
公开(公告)日：2006-10-25
申请号：EP06115792.1
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
IPC分类号： C07H21/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
摘要翻译： 公开了含有调节免疫应答的非甲基化CpG二核苷酸的核酸序列，包括刺激免疫激活，细胞因子产生，NK溶解活性和B细胞增殖的Th1模式。 序列也可用作合成佐剂。
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公开(公告)号：EP1746159A2
公开(公告)日：2007-01-24
申请号：EP06115801.0
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
IPC分类号： C12N15/11 , C07H21/04 , A61K31/7125 , A61P31/00 , A61P35/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula: 5 ′ N 1 X 1 X 2 C G T T N 2 3 ′
wherein the immunostimulatory oligonucleotide includes a modified backbone, at least one nucleotide separates consecutive CpGs, X 1 X 2 is GpT or ApT, N 1 is any nucleotide that includes a 5' TC or TG, N 1 + N 2 is from 0-26 bases, and the immunostimulatory oligonucleotide is from 8-30 bases in length and begins with TC or TG at the 5' end, with the proviso that neither N 1 nor N 2 contains a CCGG quadmer or more than one CCG or CGG trimer.摘要翻译： 包含两个或更多个未甲基化的CpG二核苷酸的分离的免疫刺激性寡核苷酸，并且具有包括下式的序列：ƒ€ƒ€ƒ€ƒ€ƒ€ƒ5'N1 X 1 X 2 CGTTN 2 3'其中 免疫刺激性寡核苷酸包括修饰的主链，至少一个核苷酸分离连续的CpG，X 1 X 2是GpT或ApT，N 1是包括5'TC或TG的任何核苷酸，N 1 + N 2是0-26个碱基， 免疫刺激寡核苷酸长度为8-30个碱基，以5'末端的TC或TG开始，条件是N 1和N 2均不含有CCGG四聚体或多于一个CCG或CGG三聚体。
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