公开(公告)号：EP1825269A2

公开(公告)日：2007-08-29

申请号：EP05853792.9

申请日：2005-12-13

申请人： UNIVERSITY OF SOUTH CAROLINA

发明人： MURPHY, Catherine J., University of S. Carolina ,  SAU, Tapan, K., c/o Punjab University ,  ORENDORFF, C.J., Biomolecular Interfaces & Systems ,  GOLE, Anand M., Inst. Bioeng. & Nanotechnology

IPC分类号： G01N33/553

CPC分类号： G01N33/553 ,  B82Y30/00 ,  G01N21/658 ,  G01N33/54373 ,  G01N2610/00 ,  Y10S436/805 ,  Y10T428/25 ,  Y10T428/2991

摘要： In one aspect, the invention relates to methods for enhancing a Raman signal comprising the steps of providing a sample comprising a metal surface, an analyte adhered to the surface, and a metallic nanoparticle coupled to the surface, wherein the nanoparticle has a plasmon resonance band; exposing the sample to incident energy of an excitation wavelength; and detecting the Raman signal of the analyte. In a further aspect, the invention relates to a composition comprising a metal surface, a functionalized self-assembled monolayer adhered to the surface, wherein the self-assembled monolayer comprises an analyte, and a cetyltrialkylammonium halide-capped metallic nanoparticle coupled to the surface. In a further aspect, the invention relates to a cetyltrimethylammonium bromide-capped gold nanoparticle and a method for preparing same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.