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1.发明公开NITRIC OXIDE-RELEASING DIAZENIUMDIOLATED POLYVINYLPYRROLIDONE-BASED POLYMERS, AND COMPOSITIONS, MEDICAL DEVICES, AND USES THEREOF 审中-公开氮氧化氮释放聚合物基于DIAZENIUMDIOLIERTEM聚乙烯吡咯烷酮和组合物，医疗器械及其用途
公开(公告)号：EP2875056A4
公开(公告)日：2016-04-06
申请号：EP13819293
申请日：2013-07-17
申请人： US HEALTH
发明人： HRABIE JOSEPH A , KEEFER LARRY K
IPC分类号： C08F26/10 , A61B5/00 , A61K8/81 , A61K31/79 , C08F226/10
CPC分类号： C08F226/10 , A61K31/79
摘要： Disclosed is a nitric oxide-releasing polyvinylpyrrolidone-based polymer derived from N-vinylpyrrolidone monomer and at least one nitric oxide releasing N2O2− group, in which the N2O2− group is attached to a 2 pyrrolidinone group or a group derived therefrom in the N-vinylpyrrolidone monomer, and the polymer is optionally in combination with a substrate. The NO-releasing polymer can be part of a medical device or pharmaceutical composition and is useful for treating a biological disorder, such as healing a wound, restenosis, and/or promoting angiogenesis.
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2.发明公开HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER 有权HYBRID氮烯鎓化合物，其药物组合物和方法治疗癌症的THAT
公开(公告)号：EP2768824A4
公开(公告)日：2015-07-08
申请号：EP12841601
申请日：2012-10-18
申请人： US HEALTH
发明人： MACIAG ANNA E , KEEFER LARRY K , SAAVEDRA JOSEPH E , JI XINHUA , KUMARI VANDANA
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D237/26 , C07D241/04
CPC分类号： A61K31/655 , A61K31/69 , A61K31/704 , A61K45/06 , C07C291/02 , C07D237/30 , C07D237/32 , C07D295/28 , C07D403/10 , A61K2300/00
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