专利检索 ap:("US SECRETARY UNITED STATES DEP") AND inv:"HELMERSON KRISTIAN PETER" 第 1 页

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发明公开
OPTICAL TRAP FOR DETECTION AND QUANTITATIONS OF SUBZEPTOMOLAR QUANTITIES OF ANALYTES 失效
标题翻译：光事件检测和定量分析SUBZEPTOMOLARER

公开(公告)号：EP0871861A4

公开(公告)日：1999-10-20

申请号：EP96921508

申请日：1996-06-07

申请人： US SECRETARY UNITED STATES DEP

发明人： WEETALL HOWARD HAYYAM , HELMERSON KRISTIAN PETER , KISHORE RANI BAKHRU

IPC分类号： G01N21/75 , G01N33/543 , G01N33/566 , G21K1/00 , H05H3/04 , G01N21/39 , G01L1/24

CPC分类号： H05H3/04 , G01N33/54313 , G01N33/54373

摘要： Tightly focused beams of laser light are used as 'optical tweezers' to trap and manipulate polarizable objects such as microspheres of glass or latex with diameters on the order of 4.5 νm. When analytes are allowed to adhere to the microspheres, small quantities of these analytes can be manipulated, thus allowing their detection and quantitation even when amounts and concentrations of the analytes are extremely small. Illustrative examples include measuring the strength needed to break antibody-antigen bonds and the detection of DNA sequences.