专利检索 ap:("USV LIMITED") AND inv:"JOSHI, Anil Purushottam, USV Limited" 第 1 页

1.

发明公开
A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE 4-AMINO-1-ISOBUTYL-1H-IMIDAZOÝ4,5-C¨-QUINOLINE (IMIQUIMOD) 审中-公开
标题翻译： METHOD FOR PRODUCING基本上纯的4-氨基-1-异丁基-1H-咪唑并[4,5-c]喹啉（咪喹莫特）

公开(公告)号：EP1831219A2

公开(公告)日：2007-09-12

申请号：EP05850947.2

申请日：2005-12-23

申请人： USV LIMITED

发明人： TARUR, Venkatasubramanian Radhakrishnan, USV Limited , KADAM, Suresh Mahadev, USV Limited , JOSHI, Anil Purushottam, USV Limited , GAVHANE, Sachin Baban, USV Limited , SAWANT, Kamlesh, Digambar , SATHE, Dhananjay, Govind , NAIK, Tushar, Anil , WADHAWA, Gurmeet, Chandramohan, Swatantra Sainik

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： A process for preparation of Imiquimod comprising oxidation of 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline (II) afforded 1-Isobutyl-1H- imidazo-[4,5-c]-quinoline-5-N-oxide(III) which is isolated in pure form as its hydrochloride salt (IV) followed by conversion to 4-chloro derivative(V) and conversion to corresponding 4-iodo derivative (VI) which is a novel intermediate. This novel intermediate is converted to imiquimod (VIII) and purified via its organic salt. The invention also relates to crystalline polymorphic forms of Imiquimod Maleate, Fumarate and Oxalate.