公开(公告)号：EP2511276A1

公开(公告)日：2012-10-17

申请号：EP10804402.5

申请日：2010-07-27

申请人： Ube Industries, Ltd.

发明人： TSUBOIKE, Kazunari ,  MIZUNO, Gen ,  NISHIDA, Hiroshi ,  KONO, Shigeyuki ,  TOYOTA, Akiko ,  TANZAWA, Fumie ,  FUJIWARA, Kosaku

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00

CPC分类号： C07D487/04

摘要： Provided is a compound represented by the Formula (I) having a HER2 inhibitory action or a pharmacologically acceptable salt thereof,

wherein T 1 is a phenyl group, an indazolyl group, or a benzofuryl group, n is an integer of 0 to 3, R 1 is a hydrogen atom, a halogen atom, a C 1-4 alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, or a C 1-4 alkoxy group, m is an integer of 0 to 3, R 2 is a hydroxy group or a C 1-4 alkyl group optionally substituted with one or two C 1-4 alkoxy groups, and R 3 is a hydrogen atom, a C 1-4 alkyl group, or a C 2-6 alkynyl group.

摘要翻译： 提供具有HER2抑制作用的式（I）表示的化合物或其药理学上可接受的盐，其中T 1为苯基，吲唑基或苯并呋喃基，n为0-3的整数，R 1为氢原子，卤原子，C 1-4烷基，C 2-6烯基，C 2-6炔基或C 1-4烷氧基，m为0〜 3，R 2是羟基或任选被一个或两个C 1-4烷氧基取代的C 1-4烷基，R 3是氢原子，C 1-4烷基或C 2- 6炔基。