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公开(公告)号：EP3797791A1
公开(公告)日：2021-03-31
申请号：EP19382827.4
申请日：2019-09-26
发明人： AGUILÓ, Juan Ignacio , MARTÍN MONTAÑES, Carlos , TARANCÓN ÍÑIGUEZ, Raquel , MATA LOZANO, Elena , URANGA MAÍZ, Santiago , VANEVA MARINOVA, Dessislava
摘要： The present invention is directed to a live-attenuated Mycobacterium tuberculosis composition comprising an isolated microorganism belonging to a M. tuberculosis MTBVAC strain having a i) PhoP- phenotype by the inactivation by a genetic deletion of the Rv0757 gene, wherein the open-reading frame (ORF) sequence of phoP consists of SEQ ID NO 4, and ii) the deletion of a second gene, Rv2930 ( fadD26 ), that prevents PDIM production (PDIM- phenotype), wherein the open-reading frame (ORF) sequence of fadD26 consists of SEQ ID NO 2, for use in therapy in a human subject in need thereof, wherein the composition is administered to said subject via pulmonary delivery.
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公开(公告)号：EP4340873A1
公开(公告)日：2024-03-27
申请号：EP20790193.5
申请日：2020-09-28
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