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公开(公告)号:EP3581176A1
公开(公告)日:2019-12-18
申请号:EP18382412.7
申请日:2018-06-12
发明人: BROTONS CANTÓ, Ana , GAMAZO DE LA RASILLA, Carlos , INCHAURRAGA CASADAMÓN, Laura , IRACHE GARRETA, Juan Manuel , MARTÍN ARBELLÁ, Nekane , MATÍAS MORO, José
摘要: The present invention relates to a core-shell nanoparticle, wherein the core is solid and comprises a zein matrix and a basic amino acid; and the shell comprises a conjugate obtained by reaction of a poly (methyl vinyl ether-co-maleic anhydride) copolymer with a compound having a reactive primary amine group. It also relates to a process for their preparation as well as their use in immunotherapy and in the treatment of disease, such as diabetes.