公开(公告)号：EP3313807A1

公开(公告)日：2018-05-02

申请号：EP16741391.3

申请日：2016-06-27

申请人： Universidade do Porto ,  Instituto de Higiene e Medicina Tropical ,  Instituto Politécnico Do Porto

发明人： DA COSTA LEÃO, Pedro Nuno ,  MARTINS, Maria Do Rosário ,  COSTA, Margarida ,  VASCONCELOS, Vítor ,  DOMINGUES, Valentina ,  NOGUEIRA, Fátima

IPC分类号： C07C43/23 ,  A61K31/09 ,  A61K39/015 ,  C12N1/00

摘要： The present disclosure relates to compounds and compositions for the treatment of malarian diseases. The compounds comprise a class of halogenated alkyl-aromatic secondary metabolites, including hierridic C, or pharmaceutically acceptable salts, esters, solvates or prodrugs thereof. The compounds comprise a halogen; C1-C6 alkyl, H, COCH3, COH, CO-alkyl, or CO-aryl; and a C3-C30 alkyl. In at least one embodiment, the compound is 3-chloro-4,6-dimethoxy-2-pentadecylphenol. The present disclosure also relates to methods of obtain the compounds from a solution comprising a cyanobacterium.

公开(公告)号：EP3313807B1

公开(公告)日：2019-11-13

申请号：EP16741391.3

申请日：2016-06-27

申请人： Universidade do Porto ,  Instituto de Higiene e Medicina Tropical ,  Instituto Politécnico Do Porto

发明人： DA COSTA LEÃO, Pedro Nuno ,  MARTINS, Maria Do Rosário ,  COSTA, Margarida ,  VASCONCELOS, Vítor ,  DOMINGUES, Valentina ,  NOGUEIRA, Fátima

IPC分类号： C07C43/23 ,  A61K31/09 ,  A61K39/015 ,  C12N1/00 ,  C12P7/22 ,  C12R1/01 ,  A61P33/06